A kind of anti-inflammatory traditional Chinese medicine compound and its preparation method and application

A compound and traditional Chinese medicine technology, applied in anti-inflammatory agents, pharmaceutical formulations, antipyretics, etc., can solve the problem of clinical efficacy not reaching the ideal level, and achieve the effects of inhibiting inflammation, high safety, and easy availability of raw materials

Active Publication Date: 2022-05-10
广西壮族自治区药物研究所有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, many research institutions at home and abroad have also carried out a lot of anti-inflammatory exploration of Chinese herbal medicines, but some clinical curative effects are far from reaching the ideal level

Method used

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  • A kind of anti-inflammatory traditional Chinese medicine compound and its preparation method and application
  • A kind of anti-inflammatory traditional Chinese medicine compound and its preparation method and application
  • A kind of anti-inflammatory traditional Chinese medicine compound and its preparation method and application

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Experimental program
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Effect test

Embodiment 1

[0039] An anti-inflammation traditional Chinese medicine compound is prepared from the following raw materials in parts by weight: 5 parts of golden fruit olive; 20 parts of gang plum; 10 parts of arhat tea;

[0040] The preparation method of described anti-inflammatory Chinese medicine compound, comprises the following steps:

[0041] (1) Take each raw medicinal material according to the number of parts by weight, use 8 times the amount of ethanol with a volume concentration of 50% of the medicinal material, heat and reflux extraction 3 times, each extraction time is 1h, filter, combine the filtrate, and concentrate the filtrate under reduced pressure to recover ethanol. dry to a thick paste;

[0042] (2) Add 8 times the amount of water to the dregs, decoct for 1 hour, filter, concentrate the filtrate, and dry it into a thick paste;

[0043] (3) Mix the two thick pastes, dry them into a dry paste, and crush them to get the product.

Embodiment 2

[0045] An anti-inflammatory traditional Chinese medicine compound is prepared from the following raw materials in parts by weight: 10 parts of Lavender, 30 parts of Gangmei, 18 parts of Arhat Tea, 18 parts of Siberian Crane, 12 parts of Scutellaria baicalensis and 18 parts of Forsythia.

[0046] The preparation method of described anti-inflammatory Chinese medicine compound, comprises the following steps:

[0047] (1) Take each raw medicinal material in parts by weight, use 10 times the amount of ethanol with a volume concentration of 60% of the medicinal material, heat and reflux extraction twice, each extraction time is 1.5h, filter, combine the filtrate, and concentrate the filtrate under reduced pressure to recover ethanol , dried into a thick paste;

[0048] (2) Add 9 times the amount of water to the dregs, decoct for 1.5 hours, filter, concentrate the filtrate, and dry it into a thick paste;

[0049] (3) Mix the two thick pastes, dry them into dry pastes, add pharmaceut...

Embodiment 3

[0051] An anti-inflammatory traditional Chinese medicine compound is prepared from the following raw materials in parts by weight: 12 parts of Lavender chinensis; 38 parts of Gangmei; 22 parts of Arhat tea; 22 parts of white crane vine;

[0052] The preparation method of described anti-inflammatory Chinese medicine compound, comprises the following steps:

[0053] (1) Take each raw medicinal material according to the number of parts by weight, use 11 times the volume concentration of the medicinal material as 65% ethanol, heat and reflux extraction twice, each extraction time is 1.5h, filter, combine the filtrate, and concentrate the filtrate under reduced pressure to recover ethanol , dried into a thick paste;

[0054] (2) Add 10 times the amount of water to the dregs, decoct for 2 hours, filter, concentrate the filtrate, and dry it into a thick paste;

[0055] (3) Mix the two thick pastes, dry them into dry pastes, add pharmaceutically acceptable carriers and make granules ...

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Abstract

The invention belongs to the technical field of traditional Chinese medicine compound, and in particular relates to an anti-inflammatory traditional Chinese medicine compound and its preparation method and application. The composition of the compound comprises the following raw materials in parts by weight: 5-15 parts of golden fruit olive, 20-45 parts of red plum, and 10 parts of arhat tea ‑25 parts, 10‑25 parts of Siberian Crane, and 6‑18 parts of Scutellaria baicalensis, 10‑25 parts of forsythia, 10‑25 parts of Nanlangen, 10‑25 parts of mountain silver flower Compound. The anti-inflammatory traditional Chinese medicine compound provided by the present invention can significantly inhibit the degree of mouse auricle swelling caused by xylene, and significantly reduce the levels of NO, IL-6 and TNF-α produced by LPS-stimulated RAW264.7 cells. Experiments have shown that the anti-inflammatory Chinese medicine compound provided by the invention has significant anti-inflammatory and anti-inflammatory effects, has definite curative effect, high safety, and easy-to-get raw materials. When it is prepared into a pharmaceutical preparation, a pharmaceutically acceptable carrier can be added. Conventional techniques of pharmacy prepare different dosage forms, which can be used to prepare drugs with anti-inflammatory effects.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine compound, and in particular relates to an anti-inflammatory traditional Chinese medicine compound and its preparation method and application. Background technique [0002] Inflammation is a basic pathological process that occurs when biological tissues are stimulated by certain stimuli, such as trauma, infection and other damage factors. Inflammation occurs locally and can also affect the whole body. The local manifestations are three basic changes: deterioration, hyperemia, exudation and hyperplasia. Redness, swelling, heat, pain and dysfunction are the five main manifestations. The whole body may have fever (fever), leukocytosis especially in acute inflammation, cell proliferation of reticuloendothelial system, and lesions of parenchymal organs. Inflammation can be infectious inflammation caused by infection, or non-infectious inflammation not caused by infection. Normally...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/59A61K36/634A61P29/00
CPCA61K36/59A61K36/185A61K36/42A61K36/39A61K36/539A61K36/634A61K36/195A61K36/355A61P29/00A61K2236/333A61K2236/331A61K2236/39A61K2236/51A61K2300/00
Inventor 苏军峰奉建芳覃仕娜梁健钦李秋燕陈子兴朱素梅
Owner 广西壮族自治区药物研究所有限公司
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