Devices and methods for the diagnosis and treatment of discogenic back pain

A technique for intervertebral disc and back pain, which is applied in the field of diagnosing discogenic back pain, diagnosing and treating discogenic back pain, and can solve problems such as small diagnosis and treatment of discogenic back pain

Pending Publication Date: 2021-08-31
WARSAW ORTHOPEDIC INC
View PDF19 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is a need for devices and methods for diagnosing and treating discogenic back pain that are less invasive than currently available standard procedures

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Devices and methods for the diagnosis and treatment of discogenic back pain
  • Devices and methods for the diagnosis and treatment of discogenic back pain
  • Devices and methods for the diagnosis and treatment of discogenic back pain

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0096] Example 1: If figure 1 As shown, the cannula of the device (eg, device 10 described herein) will be image-guided towards the dorsolateral annulus fibrosus of disc D1. For the diagnostic phase, the needle will not be advanced beyond the outermost layer of the annulus. The beveled tip of the cannula with integrated electrodes facilitates the separation of the collagen fibers of the annulus when the device is rotated parallel to the sheets of the annulus. Constant current pulses in the range of 2 to about 20 mAMP will be delivered to the outer annulus fibrosus. Consistent pain, especially evoked at the lower end of the current range, is consistent with nerve ending sensitivity and discogenic pain (eg, positive diagnosis). A syringe can then be engaged with the port of the device to administer the local anesthetic. The device can then be advanced to deliver therapeutic agents, such as anti-inflammatory drugs and / or neurotoxins, and then repositioned in a manner consisten...

example 2

[0097] Example Two: Sprague Doré rats were tested for compound action potentials evoked from the caudal disc 5 (tail) of the lumbar spinal cord when current was delivered from the device 10 to the site. After a 10mAMP current pulse is fired from the device into the primitive caudal disc, the complex evoked potential reaches the spinal cord, with an initial peak corresponding to a nerve conduction velocity (NCV) of about 8 m / s and a second peak corresponding to a nerve conduction velocity (NCV) of about 5 m / s, as Figure 5A shown. Inject 2% lidocaine (10 μL) into the intervertebral disc for at least 30 minutes to completely eliminate the evoked potential, such as Figure 5B shown.

example 3

[0098] Example Three: A test was performed to assess whether a change in position (eg, spinal flexion) would be beneficial in establishing a diagnosis of discogenic pain. For example, it was hypothesized that flexing the spine during diagnosis could potentially amplify differences in evoked potential thresholds between healthy and symptomatic discs when the patient is in a non-neutral position.

[0099] Such as Figure 6A As indicated, 8 mAMP current pulses were applied to the mid-positioned tail disc of Sprague-Dorrey rats. No eliciting compounds were detected in the lumbar spinal cord. However, if Figure 6B As shown, when the rat's tail was subsequently flexed to apply a mixed compressive / tensile strain on the caudal disc 5, the 8 mAMP pulse did produce a mixed potential that was distinguishable from noise. The results indicate that differences between healthy and symptomatic discs in the threshold current or evoked potential required to elicit consistent pain may be amp...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

A device is provided for supplying electrical current to an intervertebral disc. The device comprises a cannula having a proximal end and a distal end and a longitudinal axis therebetween. The distal end comprises a beveled tip for contacting a region of the intervertebral disc, and an electrode disposed within or on a surface of the cannula adjacent to the distal end. The electrode is configured to discharge electrical current to the region of the intervertebral disc. Methods of diagnosing and / or treating discogenic back pain are also provided.

Description

Background technique [0001] Discogenic back pain is a troublesome spinal condition in which one or more intervertebral discs are the source of the pain. It is estimated that one in three people with chronic low back pain suffers from discogenic back pain, and approximately five percent of adults suffer from the condition. [0002] The spine is made up of a series of interlocking bones called vertebrae, which are separated by intervertebral discs. The spine provides weight-bearing support for one-half of the body's mass and protects the nerves in the spine. The intervertebral disc consists of two parts: the annulus fibrosus, an outer ring-like structure, and the gelatinous nucleus pulposus inside the disc space. However, the outer third of the annulus contains nerve fibers. The intervertebral discs provide shock absorption and help the spine flex. The combination of vertebrae and intervertebral discs at each vertebral level enables motion of the spine, particularly flexion,...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61B5/00A61B5/053A61B17/34A61K45/00A61P25/00A61P29/00A61P23/02
CPCA61B2018/0044A61N1/0551A61B2017/00261A61M5/178A61N1/36017A61M5/347A61M5/34A61B5/4566A61B5/4824A61B18/1477A61B17/320068A61B18/20A61M2210/1003
Inventor J·威尔塞
Owner WARSAW ORTHOPEDIC INC
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap