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Micro-fluidic chip

A microfluidic chip and flow channel technology, applied in fluid controllers, laboratory utensils, laboratory containers, etc., can solve problems such as large volume of flow pumps

Pending Publication Date: 2021-09-10
SHANGHAI IND U TECH RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In view of the above-mentioned shortcomings of the prior art, the purpose of the present invention is to provide a microfluidic chip, which is used to solve the problem of the large volume of the flow pump in the active liquid delivery of the microfluidic chip in the prior art

Method used

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  • Micro-fluidic chip

Examples

Experimental program
Comparison scheme
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Embodiment 1

[0066] The present invention provides a microfluidic chip, please refer to figure 1 , which is a schematic structural view of the microfluidic chip, including a top cover 100, an upper channel structure layer 200, a lower channel structure layer 300, and a bottom cover 400 arranged sequentially from top to bottom, and the microfluidic chip The chip also includes piezoelectric micropumps.

[0067] Specifically, see Figure 2 to Figure 4 ,in, figure 2 It is shown as a schematic diagram of the three-dimensional structure of the upper channel structure layer 200, image 3 is shown as a top view of the upper runner structure layer, Figure 4 Shown as a bottom view of the upper flow channel structure layer, it can be seen that the upper surface of the upper flow channel structure layer 200 is provided with a liquid storage tank 201, a liquid input flow channel 202, a detection chamber 203 and a waste liquid discharge flow channel 204 , both ends of the detection chamber 203 com...

Embodiment 2

[0091] In this embodiment, the microfluidic chip described in Embodiment 1 is used, and the detection chamber of the microfluidic chip is coated with an antibody for detecting a specific substance to be detected to detect the content of the substance to be detected in the liquid sample.

[0092] As an example, the method for using the microfluidic chip includes: injecting different samples or reagents to be used into different reservoirs through the sample injection hole before the experiment starts. Each piezoelectric micropump is then operated in sequence to pump the sample or reagent into the detection chamber and complete the reaction.

[0093] Specifically, by using a plurality of said sample injection holes, the process of sequentially adding various liquids can be completed. For example, the first liquid storage tank can complete the delivery of sample liquid to the detection chamber; after a certain amount of sample liquid is delivered, use the second liquid storage ta...

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Abstract

The invention provides a micro-fluidic chip which sequentially comprises a top-layer cover plate, an upper-layer flow channel structure layer, a lower-layer flow channel structure layer and a bottom-layer cover plate from top to bottom, wherein the upper surface of the upper-layer flow channel structure layer is provided with a liquid storage tank, a liquid input flow channel, a detection chamber and a waste liquid discharge flow channel, and two ends of the detection chamber are respectively communicated with the liquid input flow channel and the waste liquid discharge flow channel; and a sample adding hole communicated with the liquid storage tank and a waste liquid hole communicated with the waste liquid discharge flow channel are formed in the top-layer cover plate. The micro-fluidic chip further comprises a piezoelectric micropump used for transmitting liquid from the liquid storage tank to the liquid input flow channel in a one-way mode, wherein the piezoelectric micropump comprises piezoelectric micropump flow channels located in the upper-layer flow channel structure layer and the lower-layer flow channel structure layer and communicated with the liquid storage tank and the liquid input flow channel, and a piezoelectric film located on the lower surface of the bottom layer cover plate and aligned with the piezoelectric micropump flow channels. The micro-fluidic chip disclosed by the invention is integrated with the piezoelectric micropump, so that active fluid control from the liquid storage tank to the detection chamber can be realized, and multi-liquid-path switching can be realized.

Description

technical field [0001] The invention belongs to the field of microfluidics and medical diagnosis, and relates to a microfluidics chip. Background technique [0002] The immunosorbent assay (enzyme linked immunosorbent assay, referred to as ELISA) based on the antigen-antibody reaction is widely used in medical diagnosis and biological research in colleges and universities. The current consumables for immunoabsorption reactions include enzyme-labeled plates, paper chromatography, and passive laminar flow. These methods respectively have room for improvement in that the amount of reagents used is large or the amount of reagents added is uncontrollable. Microfluidic integrated flow pump for active liquid delivery is one of the solutions to reduce reagent consumption and control reagent injection volume. However, most of the flow pumps used in microfluidics are relatively large, such as syringe pumps and compressed air pumps. Although there are a variety of micropump solutions...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01L3/00
CPCB01L3/50273B01L2300/0819B01L2400/0403B01L2400/0475
Inventor 吴炫烨关一民
Owner SHANGHAI IND U TECH RES INST