Preparation method and application of high-adhesion composite functional hydrogel

A technology with multiple functions and high adhesion, which is applied in the fields of pharmaceutical formula, medical science, bandages, etc., can solve the problems of single function and insufficient mechanical properties, and achieve the effect of simple preparation process, good anti-oxidation, and promotion of wound healing

Pending Publication Date: 2021-09-10
ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Aiming at the above-mentioned problems existing in the prior art, the present invention provides a preparation method and its application of a highly adhesive composite functional hydrogel, which overcomes the single function and insu

Method used

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  • Preparation method and application of high-adhesion composite functional hydrogel
  • Preparation method and application of high-adhesion composite functional hydrogel
  • Preparation method and application of high-adhesion composite functional hydrogel

Examples

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Example Embodiment

[0046] Example 1:

[0047] See image 3 , Figure 8 , Figure 9 , Figure 10 as well as Figure 12, A first embodiment of the present invention is based on acute skin lesions, such as the injuries and blunt trauma surgery and mechanical damage like a bleeding wound, a bleeding wound, and joint damage in the active site. First, the quaternary ammonium salt of hyaluronic acid and chitosan grafted dopamine was mixed uniformly, then, adding hydrogen peroxide and horseradish peroxidase in each tube, mix well, standing to wait for the glue sticking wound. The specific steps are:

[0048] 1, oxidation of hyaluronic acid (OHA): First, the balance of said take 1g HA, was added Erlenmeyer flask; 100mL deionized water, and placed in a rotor, and stirred on a magnetic stirrer for 3 hours showed significant transparent condensate can gum; secondly, weighing 0.54g of sodium periodate dissolved in 5ml of deionized water, was added dropwise a solution of HA, was stirred in the dark, after stirring for...

Example Embodiment

[0053] Example 2:

[0054] See image 3 , Figure 8 , Figure 9 with Figure 10 , A second embodiment of the present invention is applicable to bioadhesive, will wear such medical devices, sensors and other electronic products to the skin, play observation and treatment of acute injury to the skin. Hydrogels prepared by this method exhibit long-term adhesion properties of the skin can be repeated, as compared with conventional organic elastomeric matrix, this hydrogel with the skin having similar physical and mechanical properties. This particular hydrogel tightly adhered to and can be easily peeled off the skin surface and no residue. Using the method, the pressure-sensitive adhesive hydrogel into gel related products adhere to the skin. The specific steps are:

[0055] 1, oxidation of hyaluronic acid (OHA): First, the balance of said take 1g HA, was added Erlenmeyer flask; 100mL of deionized water, placed in the rotor, stirred for 3 hours on a magnetic stirrer; transparent condensat...

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Abstract

The invention discloses a preparation method and application of high-adhesion composite functional hydrogel, and the method comprises the following steps: modifying hyaluronic acid grafted dopamine, uniformly mixing with quaternary ammonium salt chitosan according to a volume ratio of 1: 1, and carrying out catalytic crosslinking by using hydrogen peroxide and horse radish peroxidase to form gel. The hydrogel can be used for constructing a multifunctional hydrogel dressing at an acute skin injury focus, and can also be applied to a biological adhesive. The hydrogel not only has adhesion performance, but also has appropriate gelling time, ultrahigh water content and swelling rate, good antioxidant, antibacterial, hemostatic and self-healing capabilities, and can remarkably promote wound healing.

Description

technical field [0001] The invention relates to the preparation technology of skin wound dressing, in particular to a preparation method and application of a high-adhesive composite functional hydrogel. Background technique [0002] Poor healing of acute skin injuries is a serious healthcare problem, and hydrogels have emerged in recent years with many advantages as novel wound dressings. There are many researches and products on the application of hydrogel dressings to wound healing, and some hydrogels have been applied to clinical or commercial production. However, the hydrogel dressings currently prepared to promote wound healing either have relatively simple functions, or the mechanical properties of the hydrogel itself are insufficient, which cannot meet the requirements of an ideal hydrogel wound dressing. This is mainly due to the single function of the hydrogel material itself and the crosslinking method of the hydrogel. It is a simple and effective method to obtai...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08L5/08A61L26/00
CPCC08J3/075A61L26/008A61L26/0066A61L26/0061A61L26/0023A61L2400/04A61L2300/404A61L2300/418A61L2300/208A61L2300/232C08J2305/08C08J2405/08C08L5/08
Inventor 张琨李建康崔龙龙李敬安
Owner ZHENGZHOU UNIV
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