Preparation method and adding method of cigarette smoke active oxygen scavenger

A technology of active oxygen scavenger and cigarettes, which is applied in the direction of preparation of tobacco, separation methods, chemical instruments and methods, etc., can solve the problems of low scavenging efficiency, poor thermal stability of natural antioxidants, single scavenging types, etc., and achieve cost saving and regulation The method is flexible and easy to control, and the effect of low preparation cost

Active Publication Date: 2021-10-08
中国人民解放军东部战区疾病预防控制中心
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention aims at the defects of existing cigarette smoke ROS removal technology, as well as the key problems of poor thermal stability, low removal efficiency and single removal type of natural antioxidants found so far, and provides a cigarette smoke active oxygen removal based on nano-cerium oxide The preparation method and the addition method of the agent, thereby reducing the health hazards of smoking

Method used

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  • Preparation method and adding method of cigarette smoke active oxygen scavenger
  • Preparation method and adding method of cigarette smoke active oxygen scavenger
  • Preparation method and adding method of cigarette smoke active oxygen scavenger

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Embodiment 1

[0074] Preparation method embodiment 1: a preparation method of a nano-cerium oxide-based cigarette smoke active oxygen scavenger, comprising:

[0075] Alan phosphoric acid modified nano-cerium oxide CeAL is used as a raw material, and the surface valence state is adjusted to form a cigarette smoke active oxygen scavenger. The cigarette smoke active oxygen scavenger is used to add to cigarette products to remove cigarette smoke. The purpose of reactive oxygen species (ROS).

[0076] The preparation method of described raw material CeAL is:

[0077] (1) Synthesis of nano-cerium oxide by microemulsion method: dissolve 0.4584g of docusate sodium (surfactant) in 30mL of toluene, add 1.5mL of cerium nitrate [Ce(NO) 3 ) 3 .6H 2 O] (0.1M) under strong magnetic stirring at room temperature for 45min. 3mL H was slowly added dropwise to the above reaction system 2 O 2 (Dropping rate: 200 μL / min), continue the reaction for 1 h, stand at room temperature for 24 h, and the synthesize...

Embodiment 2

[0080] Preparation method embodiment 2: a preparation method of a nano-cerium oxide-based cigarette smoke active oxygen scavenger, comprising:

[0081] Alan phosphoric acid modified nano-cerium oxide CeAL is used as a raw material, and the surface valence state is adjusted to form a cigarette smoke active oxygen scavenger. The cigarette smoke active oxygen scavenger is used to add to cigarette products to remove cigarette smoke. The purpose of reactive oxygen species (ROS).

[0082] The preparation method of described raw material CeAL is:

[0083] (1) Synthesis of nano-cerium oxide by microemulsion method: take 0.3 g of docusate sodium and dissolve it in 30 mL of toluene, add 1 mL of cerium nitrate [Ce(NO) 3 ) 3 .6H 2 O] (0.1M) under strong magnetic stirring at room temperature for 50min. 2mL H was slowly added dropwise to the above reaction system 2 O 2 (Dropping rate: 100 μL / min), continue the reaction for 1 h, stand at room temperature for 8 h, and the synthesized na...

Embodiment 3

[0086] Preparation method embodiment 3: a preparation method of a cigarette smoke active oxygen scavenger based on nano-cerium oxide, comprising:

[0087] Alan phosphoric acid modified nano-cerium oxide CeAL is used as a raw material, and the surface valence state is adjusted to form a cigarette smoke active oxygen scavenger. The cigarette smoke active oxygen scavenger is used to add to cigarette products to remove cigarette smoke. The purpose of reactive oxygen species (ROS).

[0088] The preparation method of described raw material CeAL is:

[0089] (1) Synthesis of nano-cerium oxide by microemulsion method: take 0.5 g of docusate sodium and dissolve it in 30 mL of toluene, add 2 mL of cerium nitrate [Ce(NO) 3 ) 3 .6H 2 O] (0.1M), under strong magnetic stirring, the reaction was carried out at room temperature for 60min. 4mL H was slowly added dropwise to the above reaction system 2 O 2 (The dropping rate is: 400 μL / min), continue the reaction for 1 h, stand at room te...

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Abstract

The invention discloses a preparation method and an adding method of a cigarette smoke active oxygen scavenger. The preparation method comprises the following steps: by taking alendronic acid modified nano cerium oxide CeAL as a raw material, carrying out surface valence state adjustment to form a cigarette smoke active oxygen scavenger which is suitable for cigarettes of different brands. The adding method comprises the following steps: adding a CeAL aqueous solution into a hookah; dropwise adding the CeAL mixed solution into tobacco leaves or a filter tip; adding CeAL powder to the junction of the filter tip and the tobacco leaves; and adding CeAL powder into the cigarette holder filter. According to the invention, nano cerium oxide CeAL is nano-particles with good dispersibility, and the nano-particles as metalloenzyme exert superoxide dismutase mimic activity, hydroxyl radical scavenging activity and catalase mimic activity, have thermal stability and are influenced by the valence state of the nano-particles and external pH to a certain extent; and when the CeAL product is added into cigarette products, active oxygen in cigarette smoke can be effectively removed, and harm of smoking to health is relieved.

Description

technical field [0001] The invention relates to the field of tobacco product additives, in particular to a preparation method and an adding method of a nano-cerium oxide-based active oxygen scavenger for cigarette smoke. Background technique [0002] The tobacco epidemic is a serious threat to human health, and smoking is recognized as an important risk factor for eight major death diseases worldwide (Lancet Oncol. 2019, 20, e208, Public Health 2016, 37, 149). During the combustion of cigarettes, a large amount of reactive oxygen species (ROS, >10 per puff) will be produced. 16 molecules), such as oxygen radicals (·O 2 - ), hydroxyl radicals ( OH), hydrogen peroxide (H 2 O 2 ), etc., the current cigarette filtering technology cannot effectively remove the above-mentioned ROS (Acad Sci. 1993, 686, 12, Nanoscale 2017, 9, 3952). These ROS are inhaled into the respiratory system through smoke, which directly damages cells, induces oxidative stress, and uses biological ma...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D53/81B01D53/78A24B3/12A24D3/04A24D3/06
CPCB01D53/81B01D53/78A24B3/12A24D3/048A24D3/061Y02A50/20
Inventor 李宏谭伟龙毛应华汪春晖荣署
Owner 中国人民解放军东部战区疾病预防控制中心
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