Preparation method of medicine suitable for cough of pets

A technology for pets and sustained-release drugs, applied in the field of drug preparation for pet cough, can solve the problems of enhancing the toxic and side effects of western medicines, reducing drug efficacy, poisoning, etc. Effect

Active Publication Date: 2021-10-29
广州中冠动物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, taking traditional Chinese medicine and western medicine at the same time may enhance the toxic and side effects of western medicine due to the complex ingredients of traditional Chinese medicine. Taking Chinese medicine and Western medicine at the same time will cause symptoms such as reduced efficacy or poisoning

Method used

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  • Preparation method of medicine suitable for cough of pets
  • Preparation method of medicine suitable for cough of pets
  • Preparation method of medicine suitable for cough of pets

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A method for slow-release drug preparation for pet cough, is made as follows:

[0027] 1. Chinese medicine dipper core preparation:

[0028] (1) Chinese medicine dipping powder preparation:

[0029] 12 copies of parastrium, 12 almonds, 40 gypsum, 7 licorice, 11 in front of the winter, 10 pieces of winter, 15 mortar, 11 copies of the above medicinal materials After 48 mesh sieves, mixed powder is collected, placed in reflow extraction tank, adding volume fraction of 65% ethanol solution, seting temperature of 75 ° C, reflux extraction 2 times, 2 hours each time, first ethanol added In order to mix the total mass of the mixed powder, the second ethanol is added to 10 times the total mass of the mixed powder, the extraction is completed, and the extract is combined, filtrate, collect the filtrate, and spare.

[0030] (2) Concentration, dry, pulverize:

[0031] The collected filtrate was placed in a vacuum concentrated tank, and the vacuum was set to -0.07 MPa, the temperature ...

Embodiment 2

[0042] A method for slow-release drug preparation for pet cough, is made as follows:

[0043] 1. Chinese medicine dipper core preparation:

[0044] (1) Chinese medicine dipping powder preparation:

[0045] 10 copies of Ma Yellow by weight, 10 almonds, 30 gypsum, 5 licorice, 10 in front of the winter, 8 pieces of winter, 12 pieces of mortal peel, 10 copies of the above medicinal materials After 40 mesh sieve, the mixed powder is collected, in the reflow extraction tank, the amount of ethanol solution having a volume fraction is 60%, and the temperature is 70 ° C, and the reflux is extracted twice. Each time it is 2 hours, the first ethanol is added. In order to mix the total mass of the mixed powder, the second ethanol is added to 10 times the total mass of the mixed powder, the extraction is completed, combined with extraction liquid, filtration, collecting the filtrate, and spare.

[0046] (2) Concentration, dry, pulverize:

[0047]The collected filtrate was placed in a vacuum co...

Embodiment 3

[0058] A method for slow-release drug preparation for pet cough, is made as follows:

[0059] 1. Chinese medicine dipper core preparation:

[0060] (1) Chinese medicine dipping powder preparation:

[0061] 15 copies of mass, 15 almonds, 50 gypsum, 8 licorices, 12 serves as the winter, 12 pieces of winter, 16 pieces of mortar, 12 copies of the above medicinal materials After 50 mesh sieve, mixed powder is collected, placed in reflow extract, adding volume fraction of 70% ethanol solution, setting temperature of 80 ° C, reflux extraction 2 times, 2 hours each time, first ethanol added In order to mix the total mass of the mixed powder, the second ethanol is added 12 times, the extraction of the total mass of the mixed powder, the end of the extraction, combined with the extract, filtrate, collect the filtrate, and spare.

[0062] (2) Concentration, dry, pulverize:

[0063] The collected filtrate was placed in a vacuum concentrated tank, and the vacuum was set to -0.08MPa, the temper...

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Abstract

A preparation method of a sustained-release medicine suitable for cough of pets comprises the following steps: preparing a traditional Chinese medicine extract core, preparing a sustained-release coating layer and preparing a quick-release coating layer; wherein the traditional Chinese medicine extract core is prepared by preparing traditional Chinese medicine extract powder from nine traditional Chinese medicines including ephedra, almond, gypsum, liquorice, radix peucedani, tussilago farfara, fructus aurantii, pericarpium citri reticulatae and scutellaria baicalensis, adding mannitol and an absolute ethyl alcohol solution of PVP-k30 into the traditional Chinese medicine extract powder, and granulating, the sustained-release coating layer is prepared by taking microcrystalline cellulose, cellulose acetate, mannitol, polyethylene glycol 400 and an ethanol solution as raw materials and coating, and the quick-release coating layer is prepared by taking ambroxol hydrochloride, loratadine, mannitol and an ethanol solution as raw materials and coating. According to the product, effective sustained release of traditional Chinese medicine components is achieved, the medicine effect can last for 12 h, the taking frequency can be reduced, western medicine components are rapidly released and can be completely released within 15 min, and the effect of rapidly taking effect on the cough symptom is achieved.

Description

Technical field [0001] The present invention relates to the technical field of pharmaceutical preparations, and more particularly to a pharmaceutical preparation method suitable for pet cough. Background technique [0002] The national economy has rapidly developed, with the growth of pets, a series of pet food, pet medicine, pet beauty and other industries, China's pet industry is constantly moving, strengthen the development of pet food, pet drugs, Cultivate pet markets, open up pet food, pharmaceutical communication, trading channels, provide pets necessary food and medicines, behind the powerful economic growth, the domestic pet market has emerged. China is the only country in which the world is completely retaining unique traditional medical theoretical system. Sino-Yucheng Pets are an important part of China's traditional veterinary medicine. It has been more than 2,000 years of application history, and Zhongcheng pet medicine has balanced yin and yang, 祛Helping, the charac...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K47/26A61K47/32A61K47/38A61K47/10A61K36/752A61K31/137A61K31/454A61P11/14A61K33/06
CPCA61K9/167A61K9/1682A61K9/1623A61K9/1635A61K47/38A61K47/10A61K36/17A61K36/736A61K33/06A61K36/484A61K36/23A61K36/28A61K36/752A61K36/539A61K31/137A61K31/4545A61P11/14A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 叶洪艳
Owner 广州中冠动物药业有限公司
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