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Preparation method of antibacterial wound dressing capable of promoting healing

A technology of wound dressing and antibacterial agent, applied in the field of biomedical materials, can solve problems such as hindering the rapid healing of wounds, and achieve the effects of good biodegradability, good biocompatibility and strong improvement

Active Publication Date: 2022-04-01
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the disadvantages of traditional dressings also hinder the rapid healing of wounds

Method used

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  • Preparation method of antibacterial wound dressing capable of promoting healing
  • Preparation method of antibacterial wound dressing capable of promoting healing
  • Preparation method of antibacterial wound dressing capable of promoting healing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The specific preparation of hydrophilic modified polylactic acid:

[0031] Dissolve 3.6g of polylactic acid and 0.4g of 4-(2-aminoethyl)-1,2-benzenediol in 20ml of hexafluoroisopropanol to form a mixed solution, and heat the solution in a water bath at a temperature of 60-80 ℃, after heating for 3-4 hours, add 3ml of sodium sulfate solution into the mixed solution, stir at room temperature for 2 hours, obtain a precipitate after cooling, and dry to obtain modified polylactic acid.

Embodiment 2

[0033] (1) Take the hydrophilic modified polylactic acid and dissolve it in hexafluoroisopropanol with an electronic analytical balance to obtain a polylactic acid solution with a mass fraction of 10% (w / w), stir magnetically at room temperature for 5 hours until the solution is completely dissolved, Add berberine at a concentration of 0.20 g / mL, and stir magnetically for 2 h at room temperature to prepare a shell spinning solution.

[0034] (2) Dissolve sodium alginate in deionized water with an electronic analytical balance to obtain a sodium alginate solution with a mass fraction of 10% (w / w), and add a cation with a volume fraction of 5% in the sodium alginate solution ( K + ) solution for ion neutralization to reduce the degree of ionization of the solution, magnetically stirred at room temperature for 6 hours, then added ascorbic acid with a concentration of 0.10 g / mL, and magnetically stirred for 2 hours at room temperature to obtain a nuclear layer spinning solution. ...

Embodiment 3

[0037] (1) Take the hydrophilic modified polylactic acid (gained in Example 1) with an electronic analytical balance and dissolve it in the solvent hexafluoroisopropanol to obtain a polylactic acid solution with a mass fraction of 11% (w / w). Stir for 4 hours until the solute is completely dissolved, add berberine at a concentration of 0.30 g / mL, and magnetically stir for 2 hours at room temperature to prepare a shell spinning solution.

[0038] (2) Dissolve sodium alginate in deionized water with an electronic analytical balance to obtain a sodium alginate solution with a mass fraction of 11% (w / w) and add a 6% cation (Li + ) solution for ion neutralization to reduce the degree of ionization of the solution, magnetically stirred at room temperature for 5 hours, then added ascorbic acid with a concentration of 0.15 g / mL, and magnetically stirred for 2 hours at room temperature to obtain a nuclear layer spinning solution.

[0039] (3) Add the two solutions of the shell spinning ...

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Abstract

The invention relates to a preparation method of an antibacterial healing-promoting wound dressing, which is characterized in that modified polylactic acid loaded with an antibacterial substance is used as a shell layer, sodium alginate loaded with healing-promoting substance ascorbic acid and subjected to cation treatment is used as a core layer, and the antibacterial healing-promoting nanofiber wound dressing is obtained through a coaxial electrostatic spinning method. The wound dressing prepared through the method has good biodegradability, biocompatibility, bioabsorbability, hydrophilicity and mechanical strength, meanwhile, the antibacterial function of berberine and the healing promoting function of ascorbic acid are fused through coaxial electrostatic spinning, and the purpose of multi-component medicine slow release is achieved; and the nanofiber membrane prepared by electrostatic spinning provides a suitable environment for tissue self-healing repair and wound healing, is lasting in antibiosis and controllable in drug loading capacity, and can accelerate wound healing.

Description

technical field [0001] The invention belongs to the field of biomedical materials, in particular to a preparation method of an antibacterial and healing-promoting wound dressing. Background technique [0002] As the first barrier of the human body, the skin undertakes the important mission of protecting human health. When the human skin is injured, it will be eroded by bacteria, leading to wound infection, and even threatening human life and health. Therefore, when the skin tissue of the human body is injured, the wound should be covered in time, and at the same time, a repairing environment should be provided for the wound to heal. Traditional wound dressings occupy the main market because of their advantages of simple production and low cost. But the disadvantages of traditional dressings also hinder the rapid healing of wounds. With people's continuous research on wounds and wound healing process, people are now using the "moisture theory" to produce new types of wound ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/46A61L15/26A61L15/28A61L15/42A61L15/20D01D5/00
Inventor 王荣武刘永昌张弘楠王黎明覃小红俞建勇
Owner DONGHUA UNIV
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