Method and device for predicting drug resistance of drug combination for preventing and controlling bacteria, and electronic equipment

Abstract

The invention provides a method and a device for predicting drug resistance of drug combination for preventing and controlling bacteria, and electronic equipment. The method comprises the following steps: according to the exposure cumulative probability distribution ECi of the drug combination, judging whether a corresponding experiment meets the possibility of bacterial drug resistance mutation or not when the concentration of the second drug is yi; if yes, obtaining a probability curve PCi of drug resistance mutation according to the minimum inhibitory concentration MICi, the mutation prevention concentration MPCi, the exposure cumulative probability distribution ECi and the inhibition rate dose response cumulative probability distribution ICi; and obtaining the offline curve area ai of the Q probability curves PCi and the corresponding occurrence probability pi when the second drug takes the concentration of yi, and obtaining the total probability of bacterial drug-resistant mutation according to the offline curve area ai and the occurrence probability pi. Simulation and prediction are implemented through the technology, and the problems that prediction of the possibility of drug-resistant mutation of bacteria based on limited experiments is not accurate enough and is lack of practicability can be solved.

Description

technical field [0001] The present application relates to the field of biotechnology, in particular, to a prediction method, device, and electronic equipment for combined drug resistance and control of bacterial drug resistance. Background technique [0002] Combination drugs are widely used in the control of drug resistance, aiming at the suppression and killing of bacterial flora at low dose levels, while preventing the emergence of bacterial drug resistance, especially multi-drug resistance, as much as possible. Under the conditions strictly controlled by the laboratory, the ratio and mode of action of the combined drug can be constantly satisfied in the narrow-spectrum region of the optimal mutation selection window period, and at the same time, it can also achieve the best resistance to the drug resistance of the bacterial flora in a specific environment. control. [0003] However, in actual application scenarios, various factors such as different dose combinations and...

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Problems solved by technology

[0004] The purpose of the embodiment of the present application is to provide a prediction method, device, and electronic equipment for combined drug resistance and control of bacterial drug resistance, so as to improve the problem of "predicting the possibility of bacterial drug resistance mutation based on limited experiments is not accurate enough and lacks practicability"

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