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A Combined Photoacoustic and Magnetic Resonance Imaging Method

An imaging method and magnetic resonance image technology, applied in the field of biomedical imaging, can solve the problems of poor contrast, unclear structure, poor reconstruction or restoration image quality improvement effect, etc.

Active Publication Date: 2022-04-15
SOUTHERN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in current methods, the prior image from the photoacoustic modality still suffers from poor contrast and unclear structure, making the quality improvement effect of the reconstructed or restored image poor.

Method used

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  • A Combined Photoacoustic and Magnetic Resonance Imaging Method
  • A Combined Photoacoustic and Magnetic Resonance Imaging Method
  • A Combined Photoacoustic and Magnetic Resonance Imaging Method

Examples

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Embodiment 1

[0032] A combined photoacoustic and magnetic resonance imaging method, comprising: performing magnetic resonance T2 sequence scanning and photoacoustic multispectral scanning on a target object to obtain a magnetic resonance image and a photoacoustic image of the target object. Image registration is performed on the magnetic resonance image and the photoacoustic image to obtain a registered magnetic resonance image. The registered MRI images are added to the regularization term to guide photoacoustic image reconstruction or image recovery.

[0033] It should be noted that, in this embodiment, the target object is an animal limb or tissue structure, and the magnetic resonance T2 sequence scan and photoacoustic multispectral scan are performed on the target object to fix the animal with an animal bracket, which can ensure that the animal limb or tissue structure is in the same position as the magnetic resonance and photoacoustic multispectral scanning. No deformation occurs duri...

Embodiment 2

[0053] A combined photoacoustic and magnetic resonance imaging method, the other features of which are the same as those in Example 1, the difference being that in this example, live mice are used as the experimental object, and the corrected photoacoustic image is restored using a commercial small Animal multispectral optoacoustic tomography system (MSOT in Vision128, iTheraMedical, Germany) was used for experimental data acquisition. The reconstructed original photoacoustic image is as follows figure 1 As shown in (a), the photoacoustic image after attenuation correction is as follows figure 1 As shown in (b), the registered MRI image is as follows figure 1 As shown in (c), the restored photoacoustic image is as figure 1 as shown in (d), figure 1 (a), (b) and (d) The lower half is the region enclosed by the black box in the upper half shown as a magnified view. figure 1 (c) The lower part is the colorbar. From figure 1 It can be seen from the figure that the contrast ...

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Abstract

A combined photoacoustic and magnetic resonance imaging method, comprising: performing magnetic resonance T2 sequence scanning and photoacoustic multispectral scanning on a target object to obtain a magnetic resonance image and a photoacoustic image of the target object; Image registration, to obtain a registered magnetic resonance image; add the registered magnetic resonance image to the regularization term, and then guide the photoacoustic image reconstruction or image restoration process. This method uses the excellent anatomical structure and gradient information of magnetic resonance images to constrain photoacoustic image reconstruction or image restoration, and the generated images have the characteristics of low noise, low artifacts, high resolution and high quality.

Description

technical field [0001] The invention relates to the field of biomedical imaging, in particular to a combined photoacoustic and magnetic resonance imaging method. Background technique [0002] Photoacoustic tomography is a molecular imaging mode with great potential, which can non-invasively quantify the physiological and biochemical processes of tissues, and provide a reliable basis for the diagnosis and treatment of diseases. As a key step in photoacoustic tomography, image reconstruction has a great influence on the quality of photoacoustic images. The accuracy of reconstructed images is affected by factors such as imperfect imaging models and noise. Furthermore, attenuation correction of photoacoustic images amplifies noise and artifacts in the images. [0003] In order to improve the quality of images, it is usually necessary to introduce appropriate constraints or prior knowledge in the process of image reconstruction or image restoration. However, in current methods...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B5/00A61B5/055G06T5/00G06T7/30
CPCA61B5/0095A61B5/0035A61B5/055G06T7/30G06T2207/10088G06T5/90G06T5/70
Inventor 陈武凡张双阳戚力
Owner SOUTHERN MEDICAL UNIVERSITY