Triple-negative breast cancer prognosis prediction device, prediction model and construction method thereof

Abstract

The invention discloses a triple-negative breast cancer prognosis prediction model construction method, which comprises the following steps: realizing collection of original gene expression data and corresponding clinical survival data of a triple-negative breast cancer sample, and obtaining a gene expression matrix after realizing standardization processing of the gene expression data; obtaining an independent cancer formation specific gene of the triple-negative breast cancer, and obtaining the expression quantity of the gene; screening out parameters for constructing a prognosis prediction model from the obtained independent cancer formation specific genes and obtaining corresponding regression coefficients, wherein the parameters are multiple gene types; and based on the screened genes, calculating a risk score according to the expression quantity and the corresponding regression coefficient of the genes to obtain a triple-negative breast cancer prognosis prediction model. The triple-negative breast cancer prognosis prediction model constructed by the invention realizes risk stratification of prognosis of triple-negative breast cancer patients, significantly separates high and low risk patients, further can predict clinical results of triple-negative breast cancer and guide individualized treatment, and has high clinical application value.

Description

technical field [0001] The invention relates to the medical field, in particular to a triple-negative breast cancer prognosis prediction device, a prediction model and a construction method thereof. Background technique [0002] Breast cancer has a variety of biological behaviors, clinicopathological features, and molecular characteristics. According to the difference of clinical diagnostic markers, breast cancer can be divided into different molecular subtypes, including luminal subtype A (luminal subtype A), luminal subtype B / C (luminal subtype B / C), normal breast-like type (normal breast- Like subtype), HER-2 over-expression subtype (HER-2 over-expression subtype) and basal-like subtype (basal-like subtypel), the clinical characteristics, treatment response and prognosis of different subtypes of breast cancer are significantly different. [0003] Triple negative breast cancer (tripie-negative breast cancer, TNBC) is a clinicopathological type of breast cancer, characteri...

AI Technical Summary

Problems solved by technology

In recent years, new developments have been made in the treatment of ICB. Although it has a certain effect on the treatment of triple-negative breast cancer, it is still not optimistic from a long-term perspective.

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