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Photothermal/photodynamic synergistic tumor phototherapy reagent and preparation method and application thereof

A photodynamic and tumor technology, applied in the field of materials and biomedicine, can solve the problems of cell hypoxia and restriction, and achieve the effects of reducing metal toxicity, increasing lifespan, and overcoming the self-quenching effect.

Active Publication Date: 2021-11-26
THE SECOND PEOPLES HOSPITAL OF SHENZHEN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although great progress has been made in recent years, its clinical application is limited due to problems such as cell hypoxia and photosensitizer aggregation.

Method used

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  • Photothermal/photodynamic synergistic tumor phototherapy reagent and preparation method and application thereof
  • Photothermal/photodynamic synergistic tumor phototherapy reagent and preparation method and application thereof
  • Photothermal/photodynamic synergistic tumor phototherapy reagent and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] A method of preparing a photothermal / photodynamic tumor phototherapy agent comprising the steps of:

[0042] First, 23 mg Pd (NO 3 ) 2 In 10 ml of deionized water, the metal palladium solution solution was prepared with a metal ion concentration of 0.01 mol / L was thoroughly stirred; 2.61 μl of 3-mercapto proppropion is added to 9997.39 μL of deionized water, and thoroughly stirring formulated into a concentration of 0.003 Mol / L of 3-mercaptopropionic acid solution; 0.6 g NaOH was added to 10 ml deionized water, and thoroughly stirred well to a sodium hydroxide solution having a concentration of 1.5 mol / L; 4.75 mg nabh 4 The addition of 2.5 ml of deionized water was stirred and mixed with a solution of sodium borohydride solution having a concentration of 0.05 mol / L.

[0043] Then, the above metal palladium salt solution was quantified to 2.35 ml of deionized water, thoroughly stirred well, and then 2 mL of the above 3-mercapto propionic acid solution was added and...

Embodiment 2

[0046] A method of preparing a photothermal / photodynamic tumor phototherapy agent comprising the steps of:

[0047] First, 46 mg Pd (NO 3 ) 2 The addition of 10 ml of deionized water was added, and the metal ion concentration was formed into a metal palladium salt solution having a metal ion concentration of 0.02 mol / L; 12.3 mg glutathione was added to 10 ml of deionized water, and thoroughly stirred with a concentration of 0.004 mol. The glutathione of the glutathione of the glutathione; 0.52 g NaOH was added to 10 ml of deionized water, and thoroughly stirred well to a sodium hydroxide solution having a concentration of 1.3 mol / L; 7.6 mg nabh 4 The addition of 2.5 ml of deionized water was added, and the fully shaken was formulated into a solution having a concentration of 0.08 mol / L;

[0048] Then, the above metal palladium salt solution was quantified to 2.35 ml of deionized water, thoroughly stirred well, and 2 mL of glutathione solution was added and stirred for 7 mi...

Embodiment 3

[0051] A method of preparing a photothermal / photodynamic tumor phototherapy agent comprising the steps of:

[0052] First, 155 mg h will 2 CL 6 Pt was added to 10 ml of deionized water, and the mixture was fully stirred into a metal platinum salt solution having a metal ion concentration of 0.03 mol / L; 4.35 μL of 3-mercaptopropionic acid was added to 9995.65 μL of deionized water, and thoroughly stirred with a concentration 0.005 mol / L of 3-mercaptopropionic acid solution; 0.4 g NaOH was added to 10 mL deionized water, and thoroughly stirred the solution of sodium hydroxide solution having a concentration of 1.0 mol / L; 9.5 mg nabh 4 The addition of 2.5 ml of deionized water was added and mixed with a solution to a concentration of 0.1 mol / L;

[0053] Then, the above metal platinum salt solution was added to 2.35 mL of deionized water, thoroughly stirred, and 2 mL of the above 3-mercapto propionic acid solution was added and stirred for 10 min, then 0.3 mL of the above Na...

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Abstract

The invention discloses a photothermal / photodynamic synergistic tumor phototherapy reagent. The photothermal / photodynamic synergistic tumor phototherapy reagent comprises a metal cluster, a photosensitizer and an MXene nanosheet material, wherein the metal cluster and the photosensitizer are loaded on the MXene nanosheet material to form an MXene nanosheet composite material. Meanwhile, the invention further discloses a preparation method of the photothermal / photodynamic synergistic tumor phototherapy reagent and application of the photothermal / photodynamic synergistic tumor phototherapy reagent. The MXene material is used for exerting the photothermal effect and the photodynamic activity, the metal cluster can be used for decomposing excessive hydrogen peroxide or water in tumor cells into oxygen, continuous oxygen supply for the photosensitizer is achieved, active oxygen species are generated, and therefore the photodynamic therapy is further enhanced; and the photothermal / photodynamic synergistic tumor phototherapy reagent is applied to photothermal / photodynamic synergistic tumor treatment to achieve the efficient tumor phototherapy effect, and the good market prospect is achieved.

Description

Technical field [0001] The present invention belongs to the field of material and biopharmaceutical techniques, relates to anti-tumor phototherapy reagents and methods and applications thereof, in particular, to a tumor phototherapy reagent and preparation methods thereof thereof in photothermal / photodynamic synergies. Background technique [0002] In recent years, the incidence and death rate of malignant tumors have gradually climbed, seriously threatening human life and health, cancer and their treatment are problems that have a long history of human beings. Traditional tumor treatment methods have certain defects, such as chemotherapy side effects, drug resistance leads to suppression of tumor growth, etc. Therefore, further development of high-efficiency and side effects, tumor targeting treatment, has become one of the most concerned topics in the field of medical field. With the continuous development of photosensitive materials and nanotechnology, phototherapy provides ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61P35/00B82Y5/00B82Y40/00
CPCA61K41/0057A61K41/0071A61K41/0052A61P35/00B82Y5/00B82Y40/00A61K2300/00
Inventor 党闪闪张斌聂国辉吴汉伟李华伟韩景宏王雨洁曾俊清
Owner THE SECOND PEOPLES HOSPITAL OF SHENZHEN
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