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Biocompatible organogel matrices for intraoperative preparation of drug delivery depot

A biocompatible, organogel technology for use in the field of intraoperatively prepared biocompatible organogel matrices for drug delivery depots

Pending Publication Date: 2021-11-26
DEPUY SYNTHES PROD INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Additionally, repeated sterilization of graphic cases is prohibitive with biodegradable antimicrobial coatings, thus requiring alternative logistics
[0010] Some of the difficulties associated with coated medical devices include limited market size in accordance with regulatory approvals, the necessity of replicating inventories, and the technical challenge of coating a wide variety of anatomical implant shapes

Method used

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  • Biocompatible organogel matrices for intraoperative preparation of drug delivery depot
  • Biocompatible organogel matrices for intraoperative preparation of drug delivery depot
  • Biocompatible organogel matrices for intraoperative preparation of drug delivery depot

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0154] metal adhesion

[0155] A 50:50 sorbitan monostearate: linoleic acid organogel matrix was applied to the bottom surface of the metal weighing boat via an aqueous medium of phosphate-buffered saline (PBS), as Figure 8A shown. The organogel matrix showed good adhesion to the metal surface of the weighing boat through the aqueous medium of PBS.

[0156] In separate experiments, three different organogel matrix formulations were applied to the bottom surface of metal weighing boats. The organogel formulations consisted of 30:70, 40:60, and 50:50 sorbitan monostearate:linoleic acid, respectively. Each formulation was force-rinsed with deionized water from a squirt bottle to simulate aqueous conditions and fluid flow that can occur in vivo. Aqueous flow did not separate the 40:60 and 50:50 organogel matrix formulations, while some separation in the 30:70 sorbitan monostearate:linoleic acid organogel matrix, but retained a visually significant amount, like Figure 8B v...

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Abstract

The present disclosure is directed to an organogel drug depot for use in delivering an active agent to a surgical site, such as an implant site, for instance an orthopedic implant site. The present disclosure is also directed to an organogel drug depot for use in a non-sterile environment and application to a non-sterile open wound site. In a further embodiment, there is disclosed a system for preparing an organogel drug depot including an organogel matrix comprising an organogelator and a biocompatible organic solvent; an active agent comprising solid particles; a container including at least one wall having an outer surface and defining a volume capable of containing the organogel matrix and active agent solid particles; and a heating component configured to contact the outer surface and supply an amount of heat to the container.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of U.S. Provisional Application No. 62 / 835,556, filed April 18, 2019, the contents of which are hereby incorporated by reference in their entirety. technical field [0003] The present disclosure relates to the perioperative and intraoperative preparation and delivery of organogel matrix drug delivery depots for local delivery of active agents to surgical sites or traumatic wounds. More specifically, embodiments of the present disclosure relate to the preparation of antimicrobial or anesthetic drug depots and their local delivery to surgical sites that include one or more implantable medical devices, such as implantable orthopedic medical devices. The present disclosure further relates to the preparation of topical drug depots formed from organogel matrices in a non-sterile environment and their application to non-sterile open wounds. Background technique [0004] Foreign bodies su...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/50A61K9/00A61K9/06A61K47/14A61L27/54
CPCA61L27/50A61L27/54A61L2400/06A61L2300/402A61L2300/404A61L2300/406A61L2300/602A61L2300/802A61K9/0024A61K9/06A61K47/12A61K47/10A61K31/7036A61P31/04A61P41/00A61K31/496A61K9/0019A61K9/145A61K31/407A61K31/7032A61K38/14A61K47/14A61K47/26
Inventor C·弗洛林D·A·安布鲁斯特S·H·克尔S·贾因J·朱利安M·比克拉姆-莱尔斯
Owner DEPUY SYNTHES PROD INC