A frame type bone joint prosthesis and its preparation method and application

A bone joint and frame type technology, applied in the field of frame type bone joint prosthesis and its preparation, can solve the problems of complicated operation and high risk, and achieve the effects of simple operation, prolonging the action time and delaying the release time.

Active Publication Date: 2022-08-05
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Not only is the operation cumbersome, but also because of the uncertain factors in the in vitro culture of chondrocytes, the risk is relatively high
[0006] At present, there is no report on the simultaneous replacement and in situ regeneration of large bones or bone joints by using a combination of frame-type bone joint prosthesis and hydrogel that promotes bone joint regeneration, thereby realizing the repair of bone joint defects

Method used

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  • A frame type bone joint prosthesis and its preparation method and application
  • A frame type bone joint prosthesis and its preparation method and application
  • A frame type bone joint prosthesis and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0076] Embodiment 1 The frame type bone joint prosthesis provided by the present invention

[0077] The frame-type bone joint prosthesis provided in this embodiment is as follows: figure 1 , figure 2 , image 3 , Figure 4 and Figure 5 shown, where figure 1 It is a split diagram of the structure of each layer of the frame bone joint prosthesis; figure 2 It is a schematic diagram of the shape and structure of the frame-type bone joint prosthesis; image 3 It is the A-A section view of the frame bone joint prosthesis; Figure 4 It is the B-B section view of the frame bone joint prosthesis; Figure 5 C-C sectional view of the frame-type bone joint prosthesis.

[0078]The material of the frame-type bone prosthesis in this embodiment can be prepared by using materials such as titanium alloy, tantalum metal, polylactic acid, PEEK material, etc. In this embodiment, it is preferably prepared by using titanium alloy material.

[0079] The frame-type bone joint prosthesis of...

Embodiment 2

[0097] Example 2 Formulation selection of hydrogel for promoting bone and joint regeneration

[0098] This example adopts the titanium alloy frame bone joint prosthesis provided in Example 1, and is divided into three groups according to different hydrogel formulations. The first group is the control group with pure GelMA hydrogel, and the second group is the control group using GelMA hydrogel. Hydrogel + osteogenic inducer group, the third group was the use of GelMA hydrogel + osteogenic induction + bone regeneration microenvironment additive group, in which GelMA hydrogel was 5% GelMA hydrogel, and the osteogenic inducer included 1 mg / ml of zoledronic acid, 100mmol / L of β-glycerophosphate, 10 - 3 mol / L dexamethasone, 500ug / ml vitamin C, bone regeneration supplements including 3mg / ml bone morphogenetic protein BMP-2, 30ug / ml fibroblast growth factor, 3ug / ml vascular endothelial growth factor, 30mg / ml of stem cell culture medium freeze-dried powder, and 0.5% LAP was used a...

Embodiment 3

[0099] Example 3 Selection of volume ratio of hydrogel and autologous bone fragments

[0100] This example adopts the titanium alloy frame type bone joint prosthesis provided in Example 1, and adopts the hydrogel formula provided in the third group of Example 2, wherein the volume ratio of hydrogel and autologous bone fragments is selected as 1:0, 1:1, 1:2, 1:3 and 1:4, to investigate the coverage effect of the gel preparation on the surface of the prosthesis with different volume ratios of hydrogel and autologous bone fragments. The results are shown in Table 1. The partial photos of the frame-type bone joint prosthesis covered with hydrogel when the volume ratios are 1:0 and 1:2, respectively, are shown in Fig. Figure 10 shown.

[0101] Table 1,

[0102]

[0103] When more autologous tissue is used, it can promote rapid regeneration and healing. It can be seen from Table 1 that when only hydrogel is contained, although the gel covers firmly and no voids remain, the la...

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Abstract

The present invention provides a frame-type bone joint prosthesis, a preparation method and application thereof. The prosthesis contains a frame structure that completely matches the defect shape of the reconstruction site, can be obtained by 3D printing technology, and is covered on the outer surface of the prosthesis. A gel preparation for promoting bone and joint regeneration, and the frame structure is also provided with a mesh layer. When the prosthesis is implanted into the body to replace the bone and joint, the frame structure provides instant mechanical support, and the osteogenic formula contained in the gel preparation effectively promotes bone growth. Joint regeneration, mesh layer helps bone and joint regeneration, application of tissue engineering bone regeneration technology to solve the problem of mechanical stability and rapid bone regeneration, making the prosthesis of the frame structure integrated with bone or bone and joint regeneration, becoming a dynamic chimera Bone tissue can effectively solve the problem of repairing large bones or bone and joint defects.

Description

[0001] The present invention requires the priority of the invention patent application with the application date of July 14, 2020, the application number of CN202010672800.3, and the title of "a 3D printing frame type bone or bone joint prosthesis". technical field [0002] The invention relates to the technical field of bone joint prostheses, in particular, to a frame-type bone joint prosthesis and a preparation method and application thereof. Background technique [0003] The repair and reconstruction of large bone or bone and joint defects caused by inflammation, tumor, and trauma is a huge clinical challenge. At present, the main treatment methods include autologous bone transplantation, allogeneic bone transplantation, bone cement filling, joint prosthesis replacement, etc., all of which have corresponding shortcomings and deficiencies. The main problems include insufficient source of autologous bone, resulting in new trauma and defects, non-integration of allogeneic bo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F2/28A61F2/30
CPCA61F2/28A61F2/30A61F2/30767
Inventor 欧阳宏伟吴宏伟
Owner ZHEJIANG UNIV
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