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Composition containing sodium alginate and polylactic acid and preparation method and application thereof

A technology of sodium alginate and polylactic acid, applied in drug delivery, pharmaceutical formulations, prostheses, etc., can solve problems such as uneven injection, redness, subcutaneous nodules, etc., achieve the effect of inhibiting the degradation rate and avoiding reconstitution operations

Active Publication Date: 2021-12-10
上海俪安医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the polylactic acid facial filler particles or microspheres in the industry are first reconstituted before clinical use. Insufficient reconstitution or polylactic acid particles or microspheres bonding, or even uneven injection will cause adverse reactions such as subcutaneous nodules or redness.

Method used

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  • Composition containing sodium alginate and polylactic acid and preparation method and application thereof
  • Composition containing sodium alginate and polylactic acid and preparation method and application thereof
  • Composition containing sodium alginate and polylactic acid and preparation method and application thereof

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Embodiment Construction

[0038] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only some of the embodiments of the present invention, but not all of them. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0039] Sodium alginate, CAS No. 9005-38-3, was purchased from Qingdao Mingyue Seaweed Group. Polylactic acid is synthesized by itself, using the commonly used synthesis methods in this field: direct polycondensation method, lactide ring-opening polymerization method, and the main molecular weight ranges include: 30,000-60,000, 60,000-80,000, and 80,000-120,000.

[0040] The embodiment provides a composition containing sodium alginate and polylactic acid.

[0041] The preparation method of polylactic acid microspheres in Examples 1 ...

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Abstract

The invention provides a composition containing sodium alginate and polylactic acid and a preparation method and application thereof, and belongs to the technical field of medical instruments. The composition comprises the following components in percentage by weight: 1-99% of absorbable polylactic acid material and 1-99% of sodium alginate gel. According to the technical scheme provided by the invention, the degradation speed of the polylactic acid material in a water environment can be inhibited, and then a pre-potted gel injection product is clinically provided, so that during clinical use, the redissolving operation before use by medical personnel is avoided, and the pre-potted gel injection product can be directly used, thereby reducing and even avoiding adverse reactions such as subcutaneous nodules and the like caused by aggregation of polylactic acid particles.

Description

technical field [0001] The present invention relates to the technical field of medical devices, in particular to the technical field of implantable medical cosmetic medical devices, in particular to a composition containing sodium alginate and polylactic acid and its preparation method and application. Background technique [0002] Polylactic acid material has good biodegradability, good mechanical strength and processing performance, and its biocompatibility is good, and the degradation product is CO 2 and H 2 O, non-toxic to the human body, is widely used in tissue engineering, orthopedic repair and fixation materials, drug delivery, and surgical sutures. It is a biomedical material approved by the US Food and Drug Administration (FDA). [0003] In recent years, the beauty industry has developed rapidly, and injectable facial fillers have also developed faster and faster, becoming an indispensable part of aesthetic medicine. There are many types of facial fillers on the...

Claims

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Application Information

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IPC IPC(8): A61L27/52A61L27/20A61L27/18A61L27/58
CPCA61L27/52A61L27/20A61L27/18A61L27/58A61L2400/06A61L2300/622C08L5/04C08L67/04
Inventor 陈陆张志玲
Owner 上海俪安医疗科技有限公司
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