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Preparation process and application of pulsatilla chinensis soluble powder

A preparation process, Pulsatilla japonica technology, applied in powder transportation, climate change adaptation, medical preparations containing active ingredients, etc., can solve the problems of high use cost, large amount of use, inconvenient use, etc.

Pending Publication Date: 2021-12-28
河南纳瑞森生物药业有限公司 +3
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The 2015 edition of "Chinese Veterinary Pharmacopoeia" included "Pulsatilla Oral Liquid", but common Pulsatilla Decoction and Pulsatilla Oral Liquid are widely used in clinical applications, which is inconvenient to use. Disadvantages such as drug administration conditions, inconvenient storage and transportation, and high cost of use

Method used

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  • Preparation process and application of pulsatilla chinensis soluble powder
  • Preparation process and application of pulsatilla chinensis soluble powder
  • Preparation process and application of pulsatilla chinensis soluble powder

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] It is made from the following medicines in weight: 400g-800g of Pulsatilla chinensis, 150g-300g of Coptis chinensis, 450g-1000g of Qinpi, 300g-600g of Cortex Phellodendri; crush the above four ingredients such as Pulsatilla chinensis, Coptis chinensis, Qinpi and Cortex Phellodendri into small pieces, and set aside for use. In: including the following steps: Step (1): As above, decoct the above-mentioned 4 flavors with water for 3 times, each time adding 10 times the amount of water for 1 hour / time, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.20~1.25(70~80℃); step (2): Add ethanol to the concentrated solution obtained in step (1) to make the alcohol content reach 75%, let it stand for 12 hours, filter the supernatant, add 75% alcohol to the residue Appropriate amount of ethanol, let it stand for 12 hours, filter, combine the ethanol solution, recover the ethanol, adjust the pH value to 5.0, refrigerate for 72 hours, filter, and a...

Embodiment 2

[0014] It is made from the medicines with the following weights: 400g of Pulsatillae Radix, 150g of Coptidis Rhizoma, 450g of Cortex Phellodendron, 300g of Phellodendron Phellodendri; the above four ingredients such as Pulsatillae Radix, Coptidis Rhizome, Pittia Chinensis and Phellodendron Phellodendron are crushed into small pieces, set aside, and obtained according to the steps described in Example 1 Pulsatilla soluble powder, each g is equivalent to 1.3g of the original drug, the usage and dosage are: drinking water or seasoning: poultry, mix 1-1.5g of pulsatilla soluble powder per 1L of water, and use it continuously for 3-5 days. It is suitable for the intestines of the digestive system of livestock and poultry. Prevention and treatment of infectious diseases.

Embodiment 3

[0016] It is made of the following medicines: 800g of Pulsatillae, 300g of Coptidis, 1000g of Cortex Phellodendron, and 600g of Cortex Phellodendri; the above four ingredients, including Pulsatilla Radix, Coptidis Rhizome, Cortex of Qin, and Cortex Phellodendron, are crushed into small pieces, set aside, and obtained according to the steps described in Example 1. Pulsatilla soluble powder, each g is equivalent to 2.7g of crude drug, usage and dosage: drinking water or seasoning: poultry, mix 1-1.5g of pulsatilla soluble powder per 1L of water, and use continuously for 3-5 days. It is suitable for the prevention and treatment of intestinal infectious diseases in the digestive system of livestock and poultry.

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Abstract

The invention relates to a preparation process and an application of a pulsatilla chinensis soluble powder. The pulsatilla chinensis soluble powder is prepared from, by weight, 400-800 g of pulsatilla chinensis, 150-300 g of coptis chinensis, 450-1000 g of cortex fraxini and 300-600 g of cortex phellodendri, the four traditional Chinese medicines serve as raw materials, an extract is obtained through smashing, multiple times of decoction, decoction merging, filtering, alcohol precipitation, ethyl alcohol recovery, filtrate concentration and reduced pressure spray drying, a proper amount of glucose is added to the extract, even mixing is conducted, smashing is conducted at the temperature of 60 DEG C or below, and drying and filtering through 80-mesh sieve and then the pulsatilla chinensis soluble powder is obtained. According to the present invention, each g of the pulsatilla chinensis soluble powder is equivalent to 1.3-2.7 g of the crude drug, and the use method and the use amount of the pulsatilla chinensis soluble powder comprise drinking water or material mixing: poultry, 1-1.5 g of the pulsatilla chinensis soluble powder is added to each 1L of water, and the obtained mixture is continuously used for 3-5 days. The pulsatilla chinensis soluble powder disclosed by the invention has the advantages of high content of effective components, no drug residue and low drug cost, can be used for large-scale breeding mixed feeding and mixed drinking drug administration, is convenient to store and transport, conforms to the characteristics of new veterinary drug preparations, and is suitable for preventing and treating intestinal infectious diseases of digestive systems of livestock and poultry.

Description

technical field [0001] The invention relates to a traditional Chinese veterinary medicine preparation capable of preventing and treating intestinal infectious diseases in the digestive tract system of livestock and poultry and its preparation process and application, especially the preparation process and application of Pulsatilla soluble powder. The invention belongs to the field of traditional Chinese medicine preparations. Background technique [0002] Gastrointestinal system infectious diseases are one of the most common diseases affecting the livestock and poultry breeding industry, especially in recent years with the emergence of mixed infections, secondary infections, and drug-resistant bacterial infections, presenting a high incidence rate, complicated disease sources, and difficult control by conventional drugs And other characteristics, bring serious losses to the breeding industry; [0003] Livestock and poultry digestive system infection is mainly clinically mani...

Claims

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Application Information

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IPC IPC(8): A61K36/756A61K9/14A61P1/00A61P31/04A61P1/12A61P33/02
CPCA61K36/71A61K36/718A61K36/63A61K36/756A61K9/145A61P1/00A61P31/04A61P1/12A61P33/02A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2300/00Y02A40/70
Inventor 杨成祥赵云生赵蕾范新蕾司俊伟孟令昭
Owner 河南纳瑞森生物药业有限公司
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