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A kind of water-based adhesive composed of peptide and zein and preparation method thereof

A water-based adhesive, corn gluten technology, applied in the field of material chemistry, can solve the problems of weak viscosity, long cycle, poor biocompatibility, etc., and achieve the effect of enhancing surface adhesion, good water impact resistance, and good mechanical properties.

Active Publication Date: 2022-07-08
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The main types of water-based adhesive materials studied at this stage include polymers and recombinant proteins, polymer materials, such as α-alkyl cyanoacrylates, polyurethane adhesives, silicone adhesives, etc. Generally, the synthesis is relatively complicated, and biological Poor compatibility (I.A. van Hees, H. Hofman, M. Dompé, J. van der Gucht, M. Kamperman, Temperature-Responsive Polyelectrolyte Complexes for Bio-Inspired Underwater Adhesives. European Polymer Journal 2020, 141, 5); and recombinant proteins Although the biocompatibility is good, the process cycle of plasmid construction, protein expression, and purification is long and complicated, and most of the recombinant proteins designed in research are much weaker than the adhesive properties of natural adhesion proteins (M.J.Brennan, B.F. Kilbride, J.J.Wilker, J.C.Liu; A bioinspired elastin-based protein for a cytocompatible underwater adhesive.Biomaterials 2017,124:116-154), for this reason, some studies reported the underwater adhesive prepared by protein and polyphenol (A.H.Hofman , I.A. van Hees, J. Yang, M. Kamperman, Bioinspired Underwater Adhesives by Using the Supramolecular Toolbox. Advanced Materials 2018, 30(19):1-38)
The underwater bonding performance of polyphenol adhesives is not ideal, and there is currently a lack of a new type of water-based adhesive with good effect.

Method used

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  • A kind of water-based adhesive composed of peptide and zein and preparation method thereof
  • A kind of water-based adhesive composed of peptide and zein and preparation method thereof
  • A kind of water-based adhesive composed of peptide and zein and preparation method thereof

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preparation example Construction

[0033] In the present invention, the method for preparing the modified zein preferably comprises: dissolving the zein in an aqueous solution of a modifier to obtain an aqueous solution of modified zein.

[0034] In the present invention, the modifier preferably includes an anionic modifier or a cationic modifier.

[0035] In the present invention, the anionic modifier preferably includes a sulfate-type modifier, a sulfonate-type modifier, a benzenesulfonate-type modifier or a carboxylate-type modifier; the sulfate-type modifier The modifier preferably includes sodium dodecyl sulfate (SDS); the sulfonate-type modifier preferably includes sodium dodecylsulfonate; the benzenesulfonate-type modifier preferably includes dodecyl Sodium benzenesulfonate; the carboxylate type modifier preferably includes sodium oleate or sodium lauroyl sarcosinate;

[0036] The cationic modifier preferably includes a quaternary ammonium salt type modifier or a primary ammonium salt type modifier; the...

Embodiment 1

[0060] Zein was modified with SDS. At 25°C, 50 mg / ml of zein was dissolved in 150 mM SDS aqueous solution, and the zein was dissolved by ultrasonication for 5 min. like figure 1 , Zein is insoluble in separate deionized water, but dissolved in SDS aqueous solution, and the surface of zein dissolved in SDS aqueous solution is negatively charged, and the number of negative charges on the surface of SDS micelles after dissolving zein has a certain reduction ( figure 2 ), indicating that SDS can not only increase the solubility of zein, but also can modify the zein, and the final surface has a certain negative charge.

[0061] Preparation of zein-thymopentin aqueous adhesive: SDS anion-modified zein and basic thymopentin were cross-linked and assembled in aqueous solution through multiple non-covalent interactions such as electrostatic and hydrogen bonds. The 100 mM thymopentin aqueous solution and the 150 mM SDS aqueous solution containing 50 mg / ml of zein were adjusted to pH 4...

Embodiment 2

[0067] Zein was modified with sodium dodecyl sulfonate: at 25°C, 50 mg / ml of zein was dissolved in a 150 mM sodium dodecyl sulfonate aqueous solution, and the zein was dissolved by ultrasonication for 5 min.

[0068] Preparation of Zein-Basic Peptide AC-KRTLRR-OH Aqueous Adhesive Non-covalent cross-linked assembly. The aqueous solution of 100 mM basic peptide AC-KRTLRR-OH and the 150 mM sodium dodecyl sulfonate aqueous solution containing 50 mg / ml zein were adjusted to pH 4.5, respectively, and the aqueous solution of basic peptide AC-KRTLRR-OH was gradually added. It is added dropwise to the corn gluten solution modified by sodium dodecyl sulfonate and shaken continuously to produce a yellow viscous water-based adhesive.

[0069] The water-based adhesive can be used to bond substrates of different materials underwater, including polyetheretherketone, stainless steel, polycarbonate, polypropylene, glass, metal titanium, wood blocks, stones, shells, etc.

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Abstract

The invention relates to an aqueous adhesive formed from zein and peptides and a preparation method thereof, belonging to the technical field of material chemistry. The zein protein of the present invention is a hydrophilic modified protein; the peptides of the present invention include: ionic straight-chain short peptides and / or ionic polypeptides; the ionic straight-chain short peptides include basic cationic peptides and / or Acidic anionic peptides; the ionic polypeptides include basic cationic polypeptides and / or acidic anionic polypeptides. The water-based adhesive of the invention has strong cohesion, stable network structure and underwater bonding performance.

Description

technical field [0001] The invention relates to the technical field of material chemistry, in particular to an aqueous adhesive composed of peptides and zein and a preparation method thereof. Background technique [0002] Water-based adhesives are environmentally friendly and can be used in water-containing environments and degraded in water environments, so water-based adhesives are widely used in various fields, especially in clinical applications. There are tissue fluids in all parts, and different wounds require water-based adhesives with better water resistance to solve problems such as hemostasis, plugging, and tissue repair. [0003] At present, there are very few medical adhesives that can be used in clinical practice. The most commonly used bioadhesive with good biocompatibility is fibrin adhesive, but the operation is complicated and the adhesion effect is poor. Therefore, more and more attention has been paid to the development of medical adhesives in recent year...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C09J189/00
CPCC09J189/00C08L2205/025C08L89/00
Inventor 李文聂俊莲
Owner JILIN UNIV
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