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Application of biomarker of intestinal flora in preparation of product for diagnosing adult immune thrombocytopenia

A technology of thrombocytopenia and biomarkers, applied in the field of biomedicine, can solve the problems of no biomarkers and lack of composition and structure of intestinal flora

Active Publication Date: 2021-12-31
PEOPLES HOSPITAL PEKING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is a lack of relevant research on the composition of intestinal flora in immune thrombocytopenia, and there is no reliable biomarker

Method used

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  • Application of biomarker of intestinal flora in preparation of product for diagnosing adult immune thrombocytopenia
  • Application of biomarker of intestinal flora in preparation of product for diagnosing adult immune thrombocytopenia
  • Application of biomarker of intestinal flora in preparation of product for diagnosing adult immune thrombocytopenia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0075] Example 1. Screening of diagnostic biomarkers for adult immune thrombocytopenia

[0076] 1. Subject information and sample collection

[0077] 1. Subject information

[0078] The subjects consisted of 49 patients with immune thrombocytopenia (ITP) and 52 healthy volunteers from the Department of Hematology, Peking University People's Hospital from February 2018 to April 2019, and all signed informed consent.

[0079] Inclusion criteria for subjects: (1) All patients meet the diagnostic criteria for ITP; (2) Patients with newly diagnosed ITP have not received any drug treatment before seeing the doctor. (3) Healthy volunteers: aged ≥ 18 years, without comorbid diseases.

[0080] Subject exclusion criteria: (1) Other secondary thrombocytopenia, including autoimmune diseases, thyroid diseases, lymphoproliferative diseases, myeloproliferative disorders (aplastic anemia and myelodysplastic syndrome), hematological malignancies , chronic liver disease, hypersplenism, immun...

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Abstract

The invention discloses application of a biomarker of intestinal flora in preparation of a product for diagnosing adult immune thrombocytopenia. According to the application, shotgun-method metagenome sequencing is carried out on an adult immune thrombocytopenia patient, and florae with abundance difference from that of a normal person are found in an intestinal tract of the immune thrombocytopenia patient for the first time. Through further screening and analyzing the differential florae, it is found that the differential florae have higher sensitivity and specificity when being used for diagnosing diseases, and it is prompted that the early discovery and auxiliary diagnosis of the adult immune thrombocytopenia can be realized by detecting the relative abundance of the florae.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and specifically relates to the application of biomarkers of intestinal flora in the preparation of products for diagnosing adult immune thrombocytopenia. Background technique [0002] Adult immune thrombocytopenia (Immune thrombocytopenia, ITP) is an autoimmune bleeding disorder characterized by isolated thrombocytopenia, and its pathogenesis is mainly due to increased antibody-mediated platelet destruction and decreased platelet production. Adult immune thrombocytopenia often manifests as skin and mucous membrane bleeding, menorrhagia, and even visceral or intracranial hemorrhage is life-threatening. [0003] The pathogenesis of immune thrombocytopenia is complex, changeable and highly heterogeneous. In recent years, new pathogenesis has been continuously revealed, providing new targets for disease treatment. Previous studies have shown that in an adult patient with immune platelets, after...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/689C12Q1/06G16H50/20C12R1/145C12R1/01
CPCC12Q1/689C12Q1/06G16H50/20C12Q2600/136G01N2333/195G01N2333/33G01N2333/265G01N2800/222Y02A50/30
Inventor 张晓辉黄晓军王亚楠刘凤琪刘晓朱晓璐何云付海霞
Owner PEOPLES HOSPITAL PEKING UNIV
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