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Materials and methods for enhanced treatment and prevention of biofilms

A biofilm and biocidal technology, applied in the field of treatment, biofilm infection, destruction and/or prevention of biofilm composition, can solve the problems of destroying innate immune homeostasis and failure to restore physiological functions

Pending Publication Date: 2021-12-31
LOCUS IP CO LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Unfortunately, however, these treatments fail to restore normal physiology and disrupt innate immune homeostasis

Method used

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Examples

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Embodiment Construction

[0026] The present invention provides compositions and methods for treating, disrupting and / or preventing biofilm formation. This includes treating, disrupting and / or preventing biofilm formation on surfaces, in a wide range of tissues and body locations in a subject, and treating and / or preventing symptoms, commensal conditions associated with biofilm-associated infections in a subject and disease development. Advantageously, the present invention enhances current methods for combating antibiotic resistant strains of pathogenic bacteria.

[0027] Definition of choice

[0028] As used herein, the term "subject" refers to a human or animal that has been infected with or is at risk of infection with a biofilm-forming pathogen. Animals can be, for example, pigs, horses, goats, cats, mice, rats, dogs, primates such as apes, chimpanzees and orangutans, guinea pigs, hamsters, cows, sheep, birds such as chickens, reptiles, fish and Any other vertebrate or invertebrate. In the con...

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PUM

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Abstract

The subject invention provides materials and methods for preventing, inhibiting or reducing biofilm formation and biofilm infections. The invention utilizes growth by-products of beneficial microorganisms to enhance the effectiveness of biocidal substances in the treatment, disruption and / or prevention of biofilms. Advantageously, the subject invention is useful against antibiotic-resistant bacterial strains, such as MRSA and certain strains of Helicobacter pylori.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to U.S. Provisional Patent Application No. 62 / 819,000, filed March 15, 2019, and U.S. Provisional Patent Application No. 62 / 846,079, filed May 10, 2019, both of which are incorporated by reference in their entirety way incorporated into this article. Background technique [0003] Antibiotics are a major tool in the treatment of infections, often based on the efficiency of microbial kill studied in the free-floating (planktonic) state, acting as single cells. For example, antibiotic efficacy quantification is performed in traditional minimum inhibitory concentration (MIC) assays. However, certain microbial growths, including many human (and other animal) infections, are now understood to be caused or exacerbated by entire microbial colonies, usually composed of microorganisms working together in a biofilm state. Biofilms comprise adherent extracellular components that surround and protec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N25/30A61K31/7012A61K38/12A61K31/661A61K31/215A61P31/04
CPCA61P31/04A61K38/14A61K45/06A61K31/4439A01N25/30A61K31/7012A61K38/12A61K31/661A61K31/215A61K31/43A61K31/545A61K31/65
Inventor 肖恩·法默肯·阿里贝克
Owner LOCUS IP CO LLC