An anti-wrinkle soluble microneedle
A soluble and microneedle technology, applied in the field of microneedles, can solve problems such as uneven moisture absorption, ineffective use of microneedles, curling of microneedle patches, etc.
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Problems solved by technology
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Examples
Embodiment 1
[0038] 1. Experimental equipment: soluble microneedle patch, support device, blister box, aluminum foil bag, desiccant and small bluetooth temperature and humidity meter.
[0039] 2. Evaluation of wrinkle degree: The evaluation of wrinkle degree is divided into 3 grades, namely no wrinkle, obvious wrinkle and severe wrinkle, among which,
[0040] No wrinkle means that the surface of the patch is flat, the total area of protrusions or depressions is less than 5% of the area of the microneedle patch, and there is no warping edge, such as figure 1 ;
[0041] The obvious wrinkle is that the surface of the patch is uneven, there are 1-2 protrusions or depressions, and the total area of the protrusions or depressions is greater than 5% of the area of the microneedle patch and less than 25% of the area of the microneedle patch, and there is no warped edge. like figure 2 ;
[0042] Serious wrinkling is the uneven surface of the patch, the number of protrusions or depressio...
Embodiment 2
[0052] The difference between this example and Example 1 is that 0.1 g of fiber desiccant is added before the hot stamping and sealing, so that the volume-to-weight ratio of the volume (cubic centimeter) of the sealed packaging bag (aluminum foil bag) and the weight of the desiccant (g) is 1600:1.
[0053] The result is as follows:
[0054] Humidity peak size: maximum 75%, minimum 37%;
[0055] Average humidity after stabilization: 59%. The specific temperature and humidity trends are as follows: Figure 5 shown.
[0056] Before the test, the microneedle had no wrinkle; the microneedle still had no wrinkle when it was unsealed, and the total area of protrusions and depressions accounted for 4% of the total area of the microneedle patch; the total area of protrusions and depressions of the microneedles did not change within 30 minutes after opening.
Embodiment 3
[0058] The difference between this example and Example 1 is that 0.5g of fiber desiccant is added before the hot stamping sealing, so that the volume-to-weight ratio of the volume (cubic centimeter) of the sealed packaging bag (aluminum foil bag) to the weight of the desiccant (g) is 320:1.
[0059] The result is as follows:
[0060] Humidity peak size: maximum 67%, minimum 30%;
[0061] Average humidity after stabilization: 40%. The specific temperature and humidity trends are as follows: Image 6 shown.
[0062] Before the test, the microneedle had no wrinkle; the microneedle still had no wrinkle when it was unsealed, and the total area of protrusions and depressions accounted for 4% of the total area of the microneedle patch; the total area of protrusions and depressions of the microneedles did not change within 30 minutes after opening.
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Abstract
Description
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Application Information
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