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3D-printing blood vessel transplantation material as well as composition and preparation method thereof

A technology of vascular transplantation and 3D printing, applied in the direction of additive processing, medical science, prosthesis, etc., can solve the problems of limited success and achieve the effect of increasing surface area, improving adverse biological reactions, and rapid growth of cells and tissues

Active Publication Date: 2022-01-11
江苏集萃新型药物制剂技术研究所有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these polymers are excellent in terms of biocompatibility, chemical stability, low toxicity, and long-term robustness, they have had limited success when used to replace small diameter vessels (<6 mm inner diameter)

Method used

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  • 3D-printing blood vessel transplantation material as well as composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] (I) Ingredients

[0056] Main frame group:

[0057] The first high molecular weight polymer A: polycaprolactone, 60 parts by weight; the molecular weight is 50kDa;

[0058] The first low molecular weight polymer B: polycaprolactone, 40 parts by weight; the molecular weight is 550Da;

[0059] The first drug: aspirin, 25 parts by weight.

[0060] Connector set:

[0061] The second high molecular weight polymer C: polycaprolactone, 70 parts by weight; the molecular weight is 50kDa;

[0062] The second low molecular weight polymer D: polycaprolactone, 30 parts by weight; molecular weight is 550Da;

[0063] The second drug: angiopoietin (Ang), 4 parts by weight.

[0064] (II) Preparation of 3D printed vascular graft materials

[0065] II1- Mix the first high-molecular-weight polymer A and the first low-molecular-weight polymer B evenly, and use SpeedMixerDAC 150.1FVZ-K to mix the mixture obtained above with aspirin for 3 minutes at a speed of 3000 rpm to obtain the pri...

Embodiment 2

[0069] (I) Ingredients

[0070] Main frame group:

[0071] The first high molecular weight polymer A: polycaprolactone, 62.5 parts by weight; the molecular weight is 40kDa;

[0072] The first low molecular weight polymer B: polycaprolactone, 37.5 parts by weight; the molecular weight is 400Da;

[0073] The first drug: aspirin, 23 parts by weight.

[0074] Connector set:

[0075] The second high molecular weight polymer C: polycaprolactone, 71.4 parts by weight; the molecular weight is 40kDa;

[0076] The second low molecular weight polymer D: polycaprolactone, 28.6 parts by weight; the molecular weight is 400Da;

[0077] The second drug: angiopoietin (Ang), 3 parts by weight.

[0078] (II) Preparation of 3D printed vascular graft materials

[0079] II1- Mix the first high-molecular-weight polymer A and the first low-molecular-weight polymer B evenly, and use SpeedMixerDAC 150.1FVZ-K to mix the mixture obtained above with aspirin for 2 minutes at a speed of 4000 rpm to ob...

Embodiment 3

[0083] (I) Ingredients

[0084] Main frame group:

[0085] The first high molecular weight polymer A: polycaprolactone, 58.8 parts by weight; the molecular weight is 60kDa;

[0086] The first low molecular weight polymer B: polycaprolactone, 41.2 parts by weight; the molecular weight is 1000Da;

[0087] The first drug: aspirin, 19 parts by weight.

[0088] Connector set:

[0089] The second high molecular weight polymer C: polycaprolactone, 66.7 parts by weight; the molecular weight is 60kDa;

[0090] The second low molecular weight polymer D: polycaprolactone, 33.3 parts by weight; the molecular weight is 1000Da;

[0091] The second drug: angiopoietin (Ang), 4 parts by weight.

[0092] (II) Preparation of 3D printed vascular graft materials

[0093] II1- Mix the first high-molecular-weight polymer A and the first low-molecular-weight polymer B evenly, and use SpeedMixerDAC 150.1FVZ-K to mix the mixture obtained above with aspirin for 4 minutes at a speed of 3500 rpm to ...

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Abstract

The invention discloses a 3D-printing blood vessel transplantation material as well as a composition and preparation method thereof. The composition of the 3D-printing blood vessel transplantation material comprises a main frame set and a connector set which are stored independently, wherein the main frame set comprises a first high-molecular-weight polymer A, a first low-molecular-weight polymer B and an optional first drug, and the connector set comprises a second high-molecular-weight polymer C, a second low-molecular-weight polymer D and an optional second drug; wherein the molecular weight of the first high-molecular-weight polymer A and the molecular weight of the second high-molecular-weight polymer C are respectively and independently 20kDa-100kDa; and the molecular weight of the first low-molecular-weight polymer B and the molecular weight of the second low-molecular-weight polymer D are respectively and independently 200Da-5,000Da. According to the 3D-printing blood vessel transplantation material disclosed by the invention, a biodegradable material is prepared into various forms of blood vessel grafts suitable for human body requirements by utilizing a 3D technology, particularly an artificial blood vessel graft as a small-diameter blood vessel.

Description

technical field [0001] The invention relates to the technical field of artificial blood vessel manufacturing, in particular to a composition of 3D printed blood vessel graft material, a 3D printed blood vessel graft material obtained from the composition of the 3D printed blood vessel graft material and a preparation method thereof. Background technique [0002] Cardiovascular disease remains by far the leading cause of death worldwide. According to statistics, 17.9 million people died of cardiovascular diseases in 2016, accounting for 31% of the total global deaths, and this burden is expected to increase to 23.6 million people worldwide by 2030. Angioplasty, stent placement, or surgical bypass grafting are common clinical approaches. For the latter technique, autologous blood vessels are still the best clinical option, but the process of harvesting blood vessels is invasive and has major limitations. Synthetic vascular grafts made of biocompatible materials could be a go...

Claims

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Application Information

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IPC IPC(8): A61L27/18A61L27/50A61L27/54A61L27/58B33Y70/10
CPCA61L27/18A61L27/507A61L27/54A61L27/58B33Y70/10A61L2300/42A61L2300/414C08L67/04
Inventor 全丹毅沈霆钧
Owner 江苏集萃新型药物制剂技术研究所有限公司
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