Method for constructing msi prediction model based on immune-related genes

An immune-related and predictive model technology, applied in the field of bioinformatics, can solve the problems of poor clinical performance, high cost, and inability to provide ICIs treatment for patients sensitive to immunotherapy, so as to achieve good prognosis and predict the effect of prognosis risk
CN113921079BActive Publication Date: 2022-03-18SICHUAN CANCER HOSPITAL
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Patents(China)
Current Assignee / Owner
SICHUAN CANCER HOSPITAL
Publication Date
2022-03-18

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Abstract

The invention relates to a method for constructing an MSI prediction model based on an immune-related gene, comprising the following steps: collecting and constructing a training set and a verification set of an immune-related MSI prediction model irMSIs from a cancer genome atlas database; selecting an immune-related gene from an immunology database, and The differential genes were screened out; according to the screened differential genes, the immune-related MSI prediction model irMSIs was constructed by the LASSO logistic regression algorithm; the prognosis risk was verified using the immune-related MSI prediction model irMSIs. The present invention provides the application of immune-related genes in the prediction of MSI status. Combined with immune-related genes, a group of characteristic genes that can stably predict MSI in digestive tract tumors, especially colon cancer, are found, and can well predict the prognosis of colon cancer risk.
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Description

technical field

[0001] The invention relates to the technical field of biological information, in particular to a method for constructing an MSI prediction model related to colon cancer based on immune-related genes. Background technique

[0002] In recent years, tumor immunotherapy for colon cancer has been considered as a treatment method that cannot be ignored, and its focus is to achieve the efficacy of identifying, controlling and eliminating tumors by activating the body's immune system. Drugs targeting immune checkpoint inhibitors (ICIs), such as cytotoxic T-lymphatic system-associated protein 4 (CTLA-4) monoclonal antibody, inhibitor of programmed death protein and its ligand (PD-1 / PD-L1 ) monoclonal antibodies, etc., have brought new hope for the treatment of various tumors, including advanced melanoma, non-small cell lung cancer and bladder cancer. Patients with colon cancer can also benefit from immunotherapy. At present, the US FDA has approved PD-1 immunotherap...

Claims

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