Application of cinobufotalin in preparation of anti-tumor immune drug

A technology of anti-tumor immunity and cinobufacin, which is applied in the field of pharmacy, can solve the problems such as anti-tumor immunity of cinobufacin, and achieve the effect of improving the body's immunity, low price and good therapeutic effect

Pending Publication Date: 2022-01-18
SHANGHAI PUTUO DISTRICT CENT HOSPITAL
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  • Abstract
  • Description
  • Claims
  • Application Information

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  • Application of cinobufotalin in preparation of anti-tumor immune drug
  • Application of cinobufotalin in preparation of anti-tumor immune drug
  • Application of cinobufotalin in preparation of anti-tumor immune drug

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Embodiment 2

[0049] Embodiment 2 Pharmacodynamics detection experiment, result and evaluation

[0050] 1. Comparison of the severity of subcutaneous tumors in mice:

[0051] After the mice were treated with CT26 cells to induce colon cancer, the blank group was given normal saline 3ml / kg by intraperitoneal injection, the oxaliplatin group was given oxaliplatin 1.5mg / kg, and the cinobufacin group was given cinobufacin 3ml / kg, the oxaliplatin + cinobufacin group was given oxaliplatin 1.5mg / kg and cinobufacin 3ml / kg. Dosage: 200 μL / only. The dosing frequency is 5 days of administration, two days of rest, and a total of 18 administrations. The length and diameter of the tumor in situ and the body weight of the mice were recorded the next day after the start of administration. Then the mice were sacrificed at the cervical spine, and the subcutaneous tumors and spleens of the mice were taken out, weighed and put into a 24-well plate prepared with normal saline.

[0052] 2. Detection of the ...

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Abstract

The invention belongs to the technical field of pharmacy, and relates to a novel pharmaceutical application of cinobufotalin, in particular to application of the cinobufotalin in preparation of an anti-tumor immune drug. Mouse colon cancer subcutaneous transplantation tumor model animal experiments prove that the cinobufotalin has a good effect on resisting tumor immunity, has no adverse reaction, can relieve mouse colon cancer subcutaneous tumor induced by colon cancer cells, and provides a good application prospect for treating, relieving or eliminating tumor immune escape and improving body immunity.

Description

technical field [0001] The invention belongs to the technical field of pharmacy and relates to the new pharmaceutical application of cinobufacin, in particular to the application of cinobufacin in the preparation of anti-tumor immune drugs. Background technique [0002] Colon cancer is currently one of the most common gastrointestinal tumors. The latest data on the epidemiology of malignant tumors show that colorectal cancer has become one of the most common cancers in humans, and the new incidence and mortality rates are among males and females. It ranks third, and the new morbidity and mortality are increasing year by year. [0003] Immunogenic death refers to the treatment of tumors with some chemical drugs and radiation. Immunogenic death (ICD) occurs in tumors, followed by high expression of damage-associated molecular patterns (DAMPs) on the cell surface, such as calreticulin CRT and adenosine triphosphate (ATP). , heat shock protein (HSP70), high mobility group box B...

Claims

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Application Information

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IPC IPC(8): A61K31/585A61K31/555A61P35/00A61P37/04C12N5/0783C12N5/0784
CPCA61K31/585A61K31/555A61P35/00A61P37/04C12N5/0639C12N5/0638C12N2500/80A61K2300/00
Inventor 殷佩浩徐可袁泽婷汪玉倩吴宏磊刘朝莲詹月萍陈进宝陈腾曹亦军王杰
Owner SHANGHAI PUTUO DISTRICT CENT HOSPITAL
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