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Peptide targeting gip and glp-2 receptors for treating bone disorders

A bone disease, X12 technology, applied in bone diseases, prostheses, specific peptides, etc.

Pending Publication Date: 2022-01-18
UNIV DANGERS +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Furthermore, the efficacy of these molecules remains moderate and, despite their application, is estimated to prevent only 50% of bone fragility with continued treatment, justifying the need to find new therapeutic pathways

Method used

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  • Peptide targeting gip and glp-2 receptors for treating bone disorders
  • Peptide targeting gip and glp-2 receptors for treating bone disorders
  • Peptide targeting gip and glp-2 receptors for treating bone disorders

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Embodiment Construction

[0018] definition

[0019] In the context of the present invention, the term "peptide" refers to natural peptides (protein hydrolysates or synthetically synthesized peptides), and further refers to mimetic peptides, such as peptidomimetic and semi-peptidomimetic peptide analogs, which may have, for example Modifications that make a peptide more stable or immunogenic in vivo. Such modifications include, but are not limited to, cyclization, N-terminal modification, C-terminal modification, acylation, PEGylation, peptide bond modification, including, but not limited to, CH 2 -NH, CH 2 -S, CH 2 -S=O, O=C-NH, CH 2 -O, CH 2 -CH 2 , S=C-NH, CH=CH or CF=CH, main chain modification and residue modification. Methods for preparing peptidomimetic compounds are well known in the art and are specifically described in Quantitative Drug Design, CA. Ramsden Gd., Chapter 17.2, F. Choplin Pergamon Press (1992).

[0020] The peptides of the invention preferably consist of at least 30 amino...

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Abstract

The present invention concerns an isolated peptide comprising the consensus amino acid sequence SEQ ID NO: 1 : HGEGSFX7SDX10 SX12X13LDKLAARDFVNWLLQTK (SEQ ID NO: 1) wherein X7 is any amino acid residue, X10 is any amino acid residue, X12 is any amino acid residue and X13 is any amino acid residue, and the use thereof in the treatment of bone disorders.

Description

technical field [0001] The present invention relates to the treatment of bone disorders. Background technique [0002] Bone fragility is currently an important public health issue. Indeed, as the population ages, the number of fractures continues to increase (377 000 fractures in France in 2013), with serious socioeconomic consequences. [0003] Bone tissue is a tissue that is continuously remodeled to adapt to mechanical stress (gravity, exercise, etc.) as well as metabolic stress (release or storage of calcium, phosphate, protein, etc.), representing a system in balance between bone formation and bone resorption. Bone remodeling is dependent on several factors, such as calcium phosphate metabolizing hormones, mechanical loading or local factors. [0004] Bone fragility occurs when there is an imbalance between bone formation and bone resorption activities, or when bone cell activity is disturbed during bone remodeling. This results in a reduction in the amount of bone t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K14/575A61K38/00C12N15/62A61K38/22A61K38/26C07K14/605
CPCC07K14/575C07K14/605A61K38/00A61P19/08A61L27/227A61L27/54A61L2300/252A61L2300/412A61L2400/06A61L2430/02A61L2430/24C07K2319/50
Inventor G·马比约A·米兹考斯卡
Owner UNIV DANGERS