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Efficient nano drug delivery equipment for cancer treatment

A high-efficiency technology for cancer treatment, applied in the field of medical devices, which can solve problems such as poor drug stability and poor gastrointestinal stability

Inactive Publication Date: 2022-01-28
JIAXING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, it can only be used as a tool for drug delivery. Since nano-drugs are not enteric-coated on the outer surface of the delivery carrier after oral administration, the drug has poor stability, is easy to dissolve, and is easily degraded by gastric acid and enzymes. Difficulties of poor stability in the gut

Method used

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  • Efficient nano drug delivery equipment for cancer treatment
  • Efficient nano drug delivery equipment for cancer treatment
  • Efficient nano drug delivery equipment for cancer treatment

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] The present invention realizes the synchronous mixing of various materials used for the treatment of cancer drugs enteric coating solid lipid nano doxorubicin is as follows figure 1 , figure 2 , image 3 , Figure 4 , Figure 5 , Figure 6 , Figure 7 , Figure 8 and Figure 9 As shown, the present invention places four sets of brackets 102 in the fixed frame assembly 1 on the operation plane, and the drug preparation barrel 203 and the auxiliary material preparation barrel 204 in the drug combination assembly 2 are respectively arranged on the top of the main board 101 in the fixed frame assembly 1. On the left side, eccentric stirring rods 206 are screwed into the medicine preparation barrel 203 and the auxiliary material preparation barrel 204, and the bottoms of the medicine preparation barrel 203 and the auxiliary material preparation barrel 204 are respectively connected with self-priming pumps 223, and two groups of electromagnetic valves 224 are respectiv...

Embodiment 2

[0058] The present invention is used for the treatment of cancer drug enteric coating solid lipid nano-doxorubicin, the coating example after the mixing of various materials is completed is as follows figure 1 , figure 2 , image 3 , Figure 7 , Figure 10 , Figure 11 and Figure 12 As shown, the outer end of the synthetic barrel seat 401 in the coating synthesis assembly 4 is fixed in a group of cross braces 103 above, the synthetic outer barrel 402 is fixedly installed in the middle of the synthetic barrel seat 401, and the synthetic outer barrel 402 The top is equipped with a synthetic barrel cover 403, a group of discharge pipes 225 communicated with the medicament preparation tank 203, another group of discharge pipes 225 communicated with the auxiliary material preparation tank 204, and a coating tube communicated with the coating solution preparation tank 302. The liquid outlet pipes 324 are all plugged and installed in the synthetic barrel cover 403, and are all...

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Abstract

The invention provides efficient nano drug delivery equipment for cancer treatment, and belongs to the technical field of medical instruments. The efficient nano drug delivery equipment comprises a fixed frame assembly, a medicament combined preparation assembly, a coating mixing preparation assembly and a coating synthesis assembly, and the whole body takes the fixed frame assembly as a mounting base; the medicament combined preparation assembly and the coating mixing assembly are arranged on the left side and the right side of a main plate in the fixed frame assembly respectively, eccentric stirring rods with the same specification are arranged on a medicament preparation barrel and an auxiliary material preparation barrel in the medicament combined preparation assembly in a rotating mode, and a coating stirring rod is arranged in a coating liquid preparation barrel in the coating mixing assembly in a rotating mode; two groups of eccentric stirring rods and the coating stirring rod are connected with a same driving motor through a transmission mechanism, so that various raw materials for preparing solid lipid nano adriamycin for cancer treatment can be simultaneously mixed, the preparation is efficient, and the automation degree is good; and meanwhile, the medicament preparation barrel, the auxiliary material preparation barrel and the coating liquid preparation barrel are all communicated with the coating synthesis assembly through pipelines, and various mixed raw materials can be added into the coating synthesis assembly for final finished product preparation.

Description

technical field [0001] The invention relates to the technical field of medical devices, in particular to a highly efficient nano drug delivery device for cancer treatment. Background technique [0002] Cancer treatment has always been the focus of the medical field, and chemotherapy is currently one of the main methods of clinical treatment of tumors. Oral administration can overcome the adverse reactions caused by injection of current clinical chemotherapy drugs and improve patient compliance. However, most chemotherapeutic drugs are water-soluble, the intestinal wall is permeable, and are easily effluxed by P-glycoprotein (P-gp), so it is difficult to achieve good therapeutic effect by oral administration. The nano drug delivery system can improve the solubility of chemotherapy drugs, and has a large specific surface area, which is beneficial to contact with the stomach and intestines and increase absorption. It is expected to become a carrier for oral delivery of chemoth...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61J3/00B01F33/81B01F33/82B01F35/30B01F35/75B01F35/93A61K31/704A61P35/00B82Y5/00B01F101/22
CPCA61J3/00A61J3/005A61K31/704A61P35/00B82Y5/00A61J2200/42
Inventor 施丽丽于海涛
Owner JIAXING UNIV