Disinfectant medicine in root canal and preparation method thereof

A root canal and drug technology, applied in the field of root canal disinfection drugs and its preparation, can solve problems such as unclear influence, and achieve the effect of improving the inhibitory effect

Active Publication Date: 2022-06-28
BEIJING STOMATOLOGY HOSPITAL CAPITAL MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The effect of chelating agents such as EDTA on the antibacterial effect of chitosan is not yet clear

Method used

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  • Disinfectant medicine in root canal and preparation method thereof
  • Disinfectant medicine in root canal and preparation method thereof
  • Disinfectant medicine in root canal and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Example 1 The effect of a single chelating agent on the bacteriostasis of three kinds of chitosan

[0036] A root canal antiseptic medicine, including chitosan, chelating agent, Tween 80 and neutralizing solution. Described neutralization solution is glacial acetic acid and 0.5M sodium hydroxide aqueous solution, and the volume ratio of the two is 3:5.

[0037] The contents of chitosan, chelating agent and Tween 80 are shown in the following table:

[0038] Table 1 Intra-root canal disinfection drug formula

[0039]

[0040]

[0041] The preparation method of the antiseptic medicine in the root canal comprises the following steps:

[0042] (1) take chitosan and add it to glacial acetic acid, stir to dissolve, then add sodium hydroxide aqueous solution, stir evenly;

[0043] (2) adding chelating agent and Tween 80 in turn, stirring evenly, to obtain the disinfectant in the root canal.

Embodiment 2

[0044] Example 2 The effect of complex chelating agent on the bacteriostasis of three kinds of chitosan

[0045] A root canal antiseptic medicine, including chitosan, chelating agent, Tween 80 and neutralizing solution. Described neutralization solution is glacial acetic acid and 0.5M sodium hydroxide aqueous solution, and the volume ratio of the two is 3:5.

[0046] The contents of chitosan, chelating agent and Tween 80 are shown in the following table:

[0047] Table 3 Intra-root canal disinfection drug formula

[0048]

[0049] The preparation method of the antiseptic drug in the root canal is the same as that in Example 1. The chelating agent is added in sequence in the order of ethylenediaminetetraacetic acid, diethylenetriaminepentaacetic acid, and ethylenediaminetetramethylenephosphonic acid, and then stirred evenly.

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PUM

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Abstract

The invention discloses a root canal disinfection medicine and a preparation method thereof, belonging to the technical field of oral medicine. The disinfectant is in liquid state, including chitosan, chelating agent and solvent. The disinfection medicine in the root canal of the present invention uses chitosan as the main active component, and uses chelating agent and surfactant Tween 80 as auxiliary agents to treat Porphyromonas dental pulp, Porphyromonas gingivalis, intermediate Prevotella had a strong inhibitory effect on the main related bacteria of root canal infection.

Description

technical field [0001] The invention belongs to the technical field of oral medicine, in particular to a root canal disinfection medicine and a preparation method thereof. Background technique [0002] Chitin is the second most abundant natural polysaccharide on earth after cellulose, and widely exists in the shells of marine arthropods, such as shrimp, crab and other crustaceans. Chitosan is the product of deacetylation of chitin. Chitosan has many unique biological activities such as antibacterial and antitumor. [0003] Ke Song et al 【 1] The research progress of the inhibitory effect of chitosan on bacteria and fungi is reviewed. It is believed that the factors affecting the antibacterial properties of chitosan are numerous and complex. Metal ions, strains, crystal forms, etc., and many factors have intertwined effects, making it difficult to evaluate the factors affecting the antibacterial properties of chitosan at present. The researchers of this patent in previous...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K33/38A61K33/30A61K31/722A61K31/198A61P1/02A61P31/02
CPCA61K33/38A61K33/30A61K31/722A61K31/198A61P1/02A61P31/02A61P31/04A61K2300/00
Inventor 刘琨侯本祥
Owner BEIJING STOMATOLOGY HOSPITAL CAPITAL MEDICAL UNIV
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