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Identification marker genetic genomes, methods and kits for identifying or classifying subtypes of breast cancer

A genetic and genomic technology, applied in the direction of biochemical equipment and methods, microbial measurement/inspection, etc., can solve the problems of high malignancy and unreached

Pending Publication Date: 2022-03-01
FUKUSHIMA MEDICAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] (2) Luminal B-like: ER is positive, it looks milder, but the proliferation marker Ki-67 shows a high value, HER-2 is also sometimes positive, and the degree of malignancy is higher
In addition, intrinsic subtype (intrinsic subtype) is based on genetic gene analysis, and it has not yet reached the stage where it can be applied to actual clinical practice from the viewpoint of reproducibility, etc.

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  • Identification marker genetic genomes, methods and kits for identifying or classifying subtypes of breast cancer
  • Identification marker genetic genomes, methods and kits for identifying or classifying subtypes of breast cancer
  • Identification marker genetic genomes, methods and kits for identifying or classifying subtypes of breast cancer

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Embodiment Construction

[0126] 1. Differential marker genetic genes for identifying or classifying subtypes of breast cancer

[0127] 1-1. Overview

[0128] The first aspect of the present invention is a gene set of differential markers capable of distinguishing subtypes (tissue types) of breast cancer. The differential marker genetic group of the present invention is composed of genes selected from at least 199 genetic gene groups, and can be measured by measuring the occurrence level of a specific gene in the genetic gene group in the test sample. Classify the sample into breast cancer histotype Luminal A, Luminal B (HER2 positive), Luminal B (HER2 negative), HER2 positive, suspected HER2 positive, triple negative, suspected normal, normal, squamous cell carcinoma, phyllodes Any type of tumor cannot be determined.

[0129] 1-2. Definition

[0130] "Breast cancer" generally refers to cancer that develops in the tissues inside the breast, such as the mammary gland and lobules. In addition, breast...

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Abstract

The present invention addresses the problem of providing an identification marker genetic genome capable of identifying or classifying breast cancer subtypes with high reproducibility by genetic gene analysis when identifying or classifying breast cancer subtypes. The present invention relates to an identification marker genetic genome for use in identifying or classifying breast cancer subtypes, the identification marker genetic genome comprising a combination of the following genetic genes: at least one genetic gene group selected from genetic gene groups consisting of groups a-o; respectively selecting a combination of at least one genetic gene from the at least one genetic gene group; the at least one genetic gene group is selected on the basis of an expected subtype to be identified or classified. The invention relates to an identification marker genetic genome.

Description

technical field [0001] The present invention relates to combinations, methods and kits of genetic markers for identifying or classifying subtypes of breast cancer. Background technique [0002] Breast cancer is not a homogeneous disease and can be classified into multiple subtypes with various characteristics. The "intrinsic subtype" proposed by Perou et al. in 2000 (Non-Patent Document 1) is the pioneer of this subtype classification. Selected 20 kinds of breast cancer tissues before and after Doxorubicin treatment, as well as between 2 kinds of primary lesions and metastatic lymph nodes, genetic genes that are more likely to change between different tumors, and made 496 kinds of intrinsic genetic groups (intrinsic gene set). Using the 496 inherent genetic genomes, cluster analysis was performed on 65 breast cancer cases, and breast cancer was classified into the following subtypes: ESR1, GATA3 and other luminal genetic genes with more ER+ / luminal like; Cytokeratin (cyto...

Claims

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Application Information

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IPC IPC(8): C12Q1/6886C12Q1/6837C12Q1/686
CPCC12Q1/6886C12Q1/6837C12Q1/686C12Q2600/112C12Q2563/107C12Q2537/165C12Q2600/158C12Q1/6874C12Q2600/156
Inventor 渡边慎哉今井顺一伊藤惠美大竹徹阿部宣子立花和之进
Owner FUKUSHIMA MEDICAL UNIVERSITY