Application of retinol in preparation of medicine for treating inflammatory bowel disease

A technology for inflammatory bowel disease and omentin, which is applied in the application field of omentin in the preparation of inflammatory bowel disease therapeutic drugs, to achieve the effect of improving intestinal inflammation

Pending Publication Date: 2022-04-08
XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In view of the above problems, the present invention provides the application of omentin in the preparation of drugs for the treatment of inflammatory bowel disease, which mainly solves some gaps in the existing research on omentin and makes up for some gaps in the treatment of intestinal inflammation

Method used

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  • Application of retinol in preparation of medicine for treating inflammatory bowel disease
  • Application of retinol in preparation of medicine for treating inflammatory bowel disease
  • Application of retinol in preparation of medicine for treating inflammatory bowel disease

Examples

Experimental program
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Embodiment Construction

[0023] The first aspect of this part explains the application of omentin :

[0024] One of them is the application of omentin in the preparation of drugs for preventing and treating inflammatory bowel disease.

[0025] In some aspects, the inflammatory bowel disease includes ulcerative colitis and Crohn's disease.

[0026] In some embodiments, the inflammatory bowel disease is DSS colitis (dextran sodium sulfate induced colitis).

[0027] The second one is the application of omentin in the preparation of preparations for inhibiting the secretion of colitis intestinal inflammatory factors.

[0028] In some modes, the colitis intestinal inflammatory factor is at least one of IL-1β, IL-1α, TNF-α, IL-6, IL-17, GM-CSF mRNA.

[0029] In some modes, the colitis intestinal inflammatory factor secretion is dextran sodium sulfate-induced colitis intestinal inflammatory factor secretion.

[0030] The third one is the application of omentin in the preparation of preparations for inhi...

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Abstract

The invention belongs to the field of research of inflammatory bowel diseases, and particularly discloses application of omentum in preparation of drugs for treating inflammatory bowel diseases. The invention relates to application of rementin in preparation of drugs for preventing and treating inflammatory bowel diseases. The invention relates to an application of omentin in preparation of a preparation for inhibiting intestinal inflammatory factor secretion of colitis. The invention relates to an application of omentin in preparation of a preparation for inhibiting intestinal inflammatory factor secretion of colitis. The invention relates to an application of an intestinal inflammatory cytokine in preparation of a preparation for inhibiting expression of omentin. According to the invention, omentum reduces secretion of intestinal inflammatory factors of colitis induced by dextran sodium sulfate (DSS), and effectively improves intestinal inflammation; meanwhile, a corresponding scheme is provided aiming at the adjustment of the omentum element.

Description

technical field [0001] The invention belongs to the research field of inflammatory bowel disease, and in particular relates to the application of omentin in the preparation of inflammatory bowel disease treatment medicine. Background technique [0002] Inflammatory bowel disease is a group of idiopathic intestinal diseases. At present, the incidence of IBD in newly industrialized countries including China is increasing, which brings a huge burden to the society and the country. The main treatment measures for IBD are anti-inflammation, hormones, immunosuppressants, biological agents, etc., but even with active treatment, about 50% of patients with moderate to severe IBD are still unable to achieve the goal of "complete mucosal healing". There is an urgent need to find new therapeutic targets to overcome the current bottleneck of IBD treatment. [0003] Omentin is a newly discovered adipokine, which is expressed in visceral fat, mesothelial cells, vascular cells, airway gobl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/19A61P1/00A61P29/00
Inventor 陶美慧付妤陈超越张颖赵溪封沁雨费孝赏
Owner XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV
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