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Method for correcting hematocrit

A hematocrit and concentration technology, applied in the direction of material resistance, etc., can solve the problems of test result deviation, single curve cannot guarantee accuracy, etc., and achieve the effect of reducing requirements, ensuring accuracy, and easy adjustment method

Pending Publication Date: 2022-04-19
无锡博慧斯生物医药科技有限公司
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Problems solved by technology

However, the general correction method adopts single-curve correction, and for samples with a large linear range of detection concentration or a large range of hematocrit, the single curve cannot guarantee the accuracy of the whole range, and it is easy to be in the extreme value or concentration of the test substance. The extreme value of hematocrit has the problem of large deviation of test results

Method used

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  • Method for correcting hematocrit
  • Method for correcting hematocrit

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Embodiment 1

[0039] S1: Detect the blood sample resistance signal of the blood sample, and the detected blood sample resistance signal is R=3610;

[0040] S2. The measured initial blood sugar current is I=5uA;

[0041] S3. By calculating the formula C according to the correlation curve between the initial analyte current I and the concentration of the detection substance 初 =k 1 *I 3 +k 2 *I 2 +k 3 *I+k 4 , to calculate the initial blood glucose concentration C 初 =16.49mmol / L;

[0042] S4. Retrieve the detection substance concentration and the corresponding correction ratio corresponding to the measured hematocrit, as follows

[0043]

[0044] When the blood sample resistance signal is R=3610, by searching the corresponding table of the measured hematocrit and the correction ratio, and by the formula A=(R 测试值 -R 2 ) / (R 1 -R 2 )*(A 1 -A 2 )+A 2 , get the following table:

[0045]

[0046] When the initial blood glucose concentration C 初 =16.49mmol / L, by formula A 矫正 =...

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Abstract

The invention provides a hematocrit correction method. The hematocrit correction method comprises the following steps: S1, detecting a blood sample resistance signal R of a blood sample; s2, measuring an initial analyte current I; s3, calculating the initial concentration C < initial > of the analyte; s4, calculating a correction proportion A correction through a correction proportion corresponding table; s5, utilizing the measured initial analyte concentration value C < final >. According to the invention, the defects in the prior art are overcome, the design is reasonable, the structure is compact, and the measured hematocrit and correction proportion corresponding table and the measured hematocrit and detection substance initial concentration corresponding table are adjusted according to the test results of the multi-batch test paper, the multi-concentration detection substance and the multi-gradient hematocrit sample; the requirement on the performance of a detection instrument is reduced, the hematocrit is corrected without using a detector capable of calculating an irregular curved surface function in a fitting manner, and the correction efficiency is improved.

Description

technical field [0001] The invention relates to the technical field of a method for correcting hematocrit, in particular to a method for correcting hematocrit. Background technique [0002] Hand-held electrochemical biosensors are easily affected by blood hematocrit when testing blood samples, thereby causing interference to test results. When the blood hematocrit is too low, because the reactant can react with the reaction enzyme membrane faster, the measurement current will increase, resulting in a high test result. In the hematocrit blood sample with a low detection limit, the measurement result can even On the contrary, when the blood hematocrit is too high, because the reaction between the reactant and the reaction enzyme membrane is slow, the measurement current is reduced, resulting in a low test result, and the deviation can even reach More than 50%, so eliminating the influence of hematocrit is one of the keys to improve the accuracy of this type of product. [00...

Claims

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Application Information

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IPC IPC(8): G01N27/06
CPCG01N27/06Y02A90/10
Inventor 华一民彭伟邹丽洁李俊林滔刘岩
Owner 无锡博慧斯生物医药科技有限公司
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