Application of FABP4 in promoting proliferation and osteogenic differentiation of mesenchymal stem cells

Abstract

The invention discloses application of FABP4 in promoting proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells. The invention discovers that the bone marrow mesenchymal stem cells with high expression of FABP4 have stronger multiplication capacity and osteogenic differentiation capacity, and the effect of promoting in-vitro multiplication and osteogenic differentiation of the bone marrow mesenchymal stem cells is achieved by promoting expression of FABP4. Therefore, the substance for promoting FABP4 expression can be used for preparing a culture medium for promoting in-vitro proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells.

Description

technical field [0001] The present invention relates to the field of stem cells, relates to stem cell culture and induced differentiation, in particular to the application of FABP4 in promoting the proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells. Background technique [0002] In clinical practice, many diseases can lead to bone destruction, and then cause bone defects. Bone regeneration has become a hot and difficult point in clinical research in recent years. In the strategy of treating bone defects, bone tissue materials are constantly innovating, from autologous bone at the beginning to allograft bone in the later stage. The clinical application is limited to a certain extent, and the allogeneic bone also brings certain troubles to the clinical application due to its immune rejection. Bone tissue engineering is crucial to the repair of bone defects. Bone tissue engineering materials for bone defect treatment are mainly composed of two p...

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Problems solved by technology

[0004] There is currently no report on the correlation between FABP4 and t

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