The invention discloses an application of
asiatic acid to promotion of
in vitro proliferation of human adipose mesenchymal stem cells and induction of chondrogenic differentiation of the human adiposemesenchymal stem cells. Researches discover that the effects of the
asiatic acid, 2,3-dicarbonyl-23-carboxy n-butyl-ursane-12-ene-28-ethyl
carboxylate and 2,3-dicarbonyl-23-carboxy isobutyl-ursane-12-ene-28-ethyl
carboxylate on the human adipose mesenchymal stem cells have commonality and difference; the
asiatic acid, the 2,3-dicarbonyl-23-carboxy n-butyl-ursane-12-ene-28-ethyl
carboxylate and the 2,3-dicarbonyl-23-carboxy isobutyl-ursane-12-ene-28-ethyl carboxylate can significantly promote the in-vitro proliferation of the human adipose mesenchymal stem cells, but the asiatic acid can promote the chondrogenic differentiation of the human adipose mesenchymal stem cells while promoting the in-vitro proliferation of the human adipose mesenchymal stem cells, and is suitable for
chondrogenesis of the human adipose mesenchymal stem cells, and the 2,3-dicarbonyl-23-carboxy n-butyl-ursane-12-ene-28-ethyl carboxylate and the 2,3-dicarbonyl-23-carboxy isobutyl-ursane-12-ene-28-ethyl carboxylate can maintain the
stem cell characteristics of the human adipose mesenchymal stem cells while promoting the
in vitro proliferation of the human adipose mesenchymal stem cells, and are suitable for rapid
in vitro proliferation of the human adipose mesenchymal stem cells as seed cells.