Novel dual-layer composite bone tissue engineering scaffold and preparation method thereof

Abstract

The invention relates to a novel dual-layer composite bone tissue engineering scaffold and a preparation method thereof. The dual-layer bone tissue engineering scaffold comprises an outer-layer bacterial cellulose membrane and an inner-layer PLGA / MWNTs electrostatic spinning porous scaffold. The synthetic material PLGA, a natural ingredient bacterial cellulose and an inorganic ingredient multi-wall carbon nanotubes are compounded together to form the composite material by using a vacuum freeze drying process and a high-pressure electrostatic spinning method. The materials have complementary advantages, and an ideal dual-layer composite bone tissue engineering scaffold of PLGA / MWNTs / bacterial cellulose, which is excellent in performance and relatively cheap, is built. The dual-layer composite bone tissue engineering scaffold of the PLGA / MWNTs / bacterial cellulose provided by the invention is simple in preparation method, and mild in condition, has good cell biocompatibility, accords with the requirements of application inside a living body, and has a good application prospect as a novel bone tissue engineering scaffold.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a novel double-layer composite bone tissue engineering scaffold and a preparation method thereof. Background technique [0002] The treatment of bone defects caused by severe trauma, tumor resection, infection, congenital malformation, etc. is a difficult problem and a huge challenge for modern medicine, and it has been an important topic of continuous in-depth research and exploration by humans for centuries. At present, the commonly used repair methods in clinic include autologous bone transplantation, allogeneic bone transplantation and the use of artificial bone, etc., but the above methods all have certain defects: autologous bone transplantation is recognized as the gold standard for bone tissue repair, but patients have to undergo autologous tissue transplantation surgery Therefore, autologous bone grafting cannot be regarded as an ideal repair method for bone defects;...

AI Technical Summary

Problems solved by technology

At present, the commonly used repair methods in clinic include autologous bone transplantation, allogeneic bone transplantation and the use of artificial bone, etc., but the above methods all have certain defects: autologous bone transplantation is recognized as the gold standard for bone tissue repair, but patients have to undergo autologous tissue transplantation surgery Therefore, autologous bone grafting cannot be regarded as an ideal repair method for bone defects; there are risks such as immune rejection and disease transmission in allogeneic bone grafting, and sometimes even endanger the patient's life; artificial bone implantation is easy to cause foreign body Rejection, infection, etc.

In contrast, natural materials are not easy to process and have limited physical properties, but natural materials have special biological activities and are generally not easy to trigger immune rejection by the recipient

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