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Application of endoximol hydrochloride in preparation of medicine for treating diseases caused by novel coronavirus

A xyphenidate hydrochloride, coronavirus technology, applied in the field of medicine, can solve problems such as no anti-new coronavirus

Pending Publication Date: 2022-05-13
中山亿维迪科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But there is no report on its anti-new coronavirus

Method used

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  • Application of endoximol hydrochloride in preparation of medicine for treating diseases caused by novel coronavirus
  • Application of endoximol hydrochloride in preparation of medicine for treating diseases caused by novel coronavirus
  • Application of endoximol hydrochloride in preparation of medicine for treating diseases caused by novel coronavirus

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Embodiment 1: the evaluation of anti-new coronavirus activity of formula (I) compound (endoxicol hydrochloride)

[0044] 1. Experimental materials

[0045] 1.1 Cells, viruses and drugs

[0046] Caco-2 cells were purchased from ATCC (product number: HTB-037).

[0047] Live SARS-CoV-2 virus (No. IVCAS 6.7512).

[0048] The compound of formula (I) (CAS: 1032008-74-4) was purchased from Sigma.

[0049] 1.2 Reagents

[0050] DMEM medium and FBS were purchased from GIBCO; CCK8 cell viability detection kit was purchased from Thermofisher; SYBR mixture (iTaq TM Universal Green Supermix) was purchased from Bio-Rad Company.

[0051] 1.3 Experimental Instruments

[0052] Quantitative PCR instrument (Bio-Rad CFX96 Touch TM Real-Time PCR detection system) was purchased from Bio-Rad Company. A multi-label microplate reader was purchased from PerkinElmer. 1.0R refrigerated centrifuge and cell culture box were purchased from Thermofisher Company.

[0053] 2. Experimental met...

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Abstract

The invention discloses an application of endoximol hydrochloride in preparation of a medicine for preventing and / or treating diseases caused by novel coronavirus. The endoximol hydrochloride is a small molecule compound, and the CC50 of the endoximol hydrochloride is 124.7 [mu] M. It is found for the first time that the endoximol hydrochloride can inhibit the replication of the novel coronavirus SARS-CoV-2 in a dose-dependent mode, the IC50 (half inhibitory concentration) of the endoximol hydrochloride is 0.91 mu M in cells and 0.77 mu M outside cells, and the selection index (SI) of the endoximol hydrochloride is about 137 (in cells) and 162 (outside cells), so that the endoximol hydrochloride is a low-toxicity and high-efficiency medicine for resisting the novel coronavirus SARS-CoV-2.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to the application of Endoxifen hydrochloride (CAS: 1032008-74-4) in the preparation of drugs for preventing and / or treating diseases caused by novel coronaviruses. Background technique [0002] Novel coronavirus (SARS-CoV-2) is the causative agent of novel coronavirus pneumonia (COVID-19). Both SARS-CoV-2 and SARS-CoV viruses belong to the Coronaviridae family and belong to the genus Coronaviridae. SARS-CoV-2 is a positive-sense single-stranded RNA coronavirus. The length of its RNA sequence is about 30kb. The outer membrane of the COVID-19 virion is composed of four structural proteins, including N protein (Nucleocapsid, nucleocapsid protein), S protein (Spikeprotein), E protein (Envelopeprotein) and M protein (Membrane protein). The S protein determines the host range and specificity of the virus. So far, there is no specific drug that can cure the new type of coronavirus pn...

Claims

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Application Information

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IPC IPC(8): A61K31/138A61P31/14
CPCA61K31/138A61P31/14
Inventor 邬开朗刘芳郭铭王欣向文杰张艳朱莹黄智强祝成亮
Owner 中山亿维迪科技有限公司