Lung adenocarcinoma prognosis prediction method and device based on lipid metabolism genes
A prediction method and technology of prediction device, applied in prediction, genomics, biochemical equipment and methods, etc., can solve problems such as unsatisfactory prognosis and limited treatment options for lung adenocarcinoma, and achieve stable prediction performance and good prognosis effect. , the effect of strong robustness
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[0041] This embodiment provides a method for predicting the prognosis of lung adenocarcinoma based on lipid metabolism genes, comprising the following steps:
[0042] S1: Obtain a sample to be tested, and detect the RNA expression levels of multiple genes in the sample to be tested, including GAPDH gene, GNPNAT1 gene, HTATIP2 gene, MFI2 gene, PKP2 gene, RGS20 gene and CHRDL1 gene;
[0043] S2: Calculate the lung adenocarcinoma prognostic risk score according to the detected RNA expression levels of multiple genes.
[0044] Most preferably, the calculation expression of the lung adenocarcinoma prognostic risk score is:
[0045] RiskScore 7 =-0.0103*exp CHRDL1 +0.0001*exp GAPDH +0.0105*exp GNPNAT1 +0.0039*exp HTATIP2 +0.0064*exp MFI2 +0.0085*exp PKP2 +0.0284*exp RGS20
[0046] In the formula, RiskScore 7 Prognostic risk score for lung adenocarcinoma, exp CHRDL1 is the result of the expression level of CHRDL1 gene based on the natural constant e, exp GAPDH is the expr...
Embodiment approach
[0047] As an optional implementation, the method further includes: loading the detected RNA expression levels of multiple genes into a pre-established and trained classifier, calculating the lung adenocarcinoma prognostic risk score, and classifying the lung adenocarcinoma Samples whose prognostic risk score is greater than the preset risk threshold are classified as high-risk group, otherwise they are classified as low-risk group.
[0048] In this example, calculate the RiskScore 7 After that, the RiskScore 7 Perform Z-score transformation into Risk Score (data standardization), and divide samples with Risk Score greater than zero into the high-risk group, and samples less than zero into the low-risk group.
[0049] This embodiment also provides a lung adenocarcinoma prognosis prediction device based on lipid metabolism genes, including:
[0050] The data acquisition module is configured to: acquire the RNA expression levels of multiple genes in the sample to be tested, the...
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