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Adjuvant containing risedronate zinc aluminum and application thereof

A technology of zinc risedronate and risedronate, which is applied to medical preparations containing active ingredients, organic chemistry, antiviral agents, etc., can solve the problems of weak immunogenicity, etc. medicinal effect

Pending Publication Date: 2022-05-17
XIAMEN UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The subunit protein vaccine expressed by recombinant DNA technology has good safety and can achieve multi-shot booster immunization, but its immunogenicity is weak

Method used

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  • Adjuvant containing risedronate zinc aluminum and application thereof
  • Adjuvant containing risedronate zinc aluminum and application thereof
  • Adjuvant containing risedronate zinc aluminum and application thereof

Examples

Experimental program
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Effect test

preparation example

[0138] The reagents used in the preparation example are as follows:

[0139] Risedronate Sodium (C 7 h 10 NNaO 7 P 2 ), purchased from Hunan Huateng Pharmaceutical Co., Ltd.;

[0140] Anhydrous Zinc Chloride (ZnCl 2 ), purchased from Xilong Chemical Industry;

[0141] Aluminum Chloride Hexahydrate (AICl 3 ·6H 2 O), purchased from Xilong Chemical Industry;

[0142] Disodium hydrogen phosphate dodecahydrate (Na 2 HPO 4 12H 2 O), purchased from Xilong Chemical Industry;

[0143] Sodium hydroxide (NaOH), purchased from Xilong Chemical Industry

preparation example 1

[0144] Preparation Example 1: Preparation of Risedronate Zinc Aluminum Adjuvant (FH002C)

[0145] (1) Solution preparation:

[0146] According to the Zn / Al / risedronic acid molar concentration ratio of 1:0.1:0.22, prepare 0.5L (47mM zinc chloride+4.7mM aluminum chloride) solution, which is defined as A solution; prepare 0.5L (10.3mM risedronic acid Acid + 55mM sodium hydroxide + 63 mM disodium hydrogen phosphate) solution, defined as B solution, A solution and B solution were filtered with a 0.22 μm filter membrane for later use.

[0147] (2) Preparation of risedronate zinc aluminum adjuvant FH002C suspension:

[0148] Prepare the risedronate zinc aluminum adjuvant by co-precipitating the A and B solutions according to the volume ratio of 1:1, that is, the prepared B solution is added drop by drop according to the volume ratio of 1:1 until A is completely added A suspension formed from a solution. The suspension obtained after mixing was sterilized once at 121°C for 60 minut...

preparation example 2

[0149] Preparation Example 2: Preparation of risedronate zinc aluminum adjuvant (FH002C) with different ratios of zinc, aluminum and risedronic acid

[0150] (1) Solution preparation:

[0151]With the molar concentration of Zn as 1, the designed Zn / Al / risedronic acid molar concentration ratio is 1: 0.02: 0.1, 1: 0.02: 0.15, 1: 0.02: 0.22, 1: 0.02: 0.33, 1: 0.02: 0.5, 1:0.02:1 and 1:0.05:0.1, 1:0.05:0.15, 1:0.05:0.22, 1:0.05:0.33, 1:0.05:0.5, 1:0.05:1 and 1:0.1:0.1, 1: 0.1: 0.15, 1: 0.1: 0.22, 1: 0.1: 0.33, 1: 0.1: 0.5, 1: 0.1: 1 and 1: 0.15: 0.1, 1: 0.15: 0.15, 1: 0.15: 0.22, 1: 0.15:0.33, 1:0.15:0.5, 1:0.15:1 and 1:0.25:0.1, 1:0.25:0.15, 1:0.25:0.22, 1:0.25:0.33, 1:0.25:0.5, 1:0.25: 1 and 1:0.5:0.1, 1:0.5:0.15, 1:0.5:0.22, 1:0.5:0.33, 1:0.5:0.5, 1:0.5:1, prepare 0.5L (47mM zinc chloride+0.94, 2.35, 4.7, 7.05, 11.75, 23.5mM aluminum chloride) solution, defined as A solution; prepare 0.5L (4.7, 7.05, 10.3, 15.51, 23.5, 47mM risedronic acid + 35-250mM sodium hydroxide + 63 mM...

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PUM

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Abstract

The invention relates to an adjuvant containing zinc aluminum risedronate, an immunogenic composition containing the adjuvant and an immunogen, and application of the adjuvant and the immunogenic composition.

Description

technical field [0001] This application relates to the technical field of biopharmaceuticals. Specifically, the present application relates to an adjuvant containing zinc aluminum risedronate, an immunogenic composition comprising the adjuvant and an immunogen, and uses of the adjuvant and the immunogenic composition. [0002] technical background [0003] Adjuvants are substances or mixtures that can specifically or non-specifically bind to immunogens, and stimulate and induce the body to produce long-term and effective specific immune responses. The immunobiological effects of adjuvants include reducing the amount of immunogen used, enhancing the immunogenicity of the antigen, and changing the type of immune response. Adjuvants currently approved for use in human vaccines include aluminum adjuvants, MF59, AS04, and AS01 B , CpG1018, etc., and several new adjuvants are in clinical trials, including: AS03, RC-529, Advax, Matrix-M, etc. Aluminum adjuvant is the first adjuva...

Claims

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Application Information

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IPC IPC(8): A61K39/39A61K39/215A61K39/25A61K39/145A61K39/15A61P31/14C07F9/58
CPCA61K39/39A61K39/12A61P31/14A61P37/04A61P31/22A61P31/16C07F9/58A61K2039/55511A61K2039/552A61K2039/572A61K2039/575A61K2039/54A61K2039/541A61K2039/542A61K2039/543C12N2770/20034C12N2710/16734C12N2760/16134C12N2720/12334A61K2300/00A61P31/12Y02A50/30A61K2039/55505A61K31/663A61K33/06A61K33/30A61K39/145A61K39/15A61K39/215A61K39/25
Inventor 赵勤俭黄小芬聂梅凤张志刚袁权张天英李少伟夏宁邵
Owner XIAMEN UNIV
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