Cell-penetrating peptide/phospholipid polymer modified liposome emulsion suitable for eye skin as well as preparation and application of cell-penetrating peptide/phospholipid polymer modified liposome emulsion

A technology of penetrating peptides and liposomes, which is applied in skin care preparations, cosmetic preparations, medical preparations containing active ingredients, etc., can solve problems such as instability, difficulty in storage, and difficult absorption by the skin, and achieve improved Stability, prevent cell aging, prevent non-specific adsorption effect

Pending Publication Date: 2022-05-27
HANGZHOU NUOSHEN TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] The above-mentioned active ingredients such as catechin, linseed oil, vitamin A and vitamin B12 are either unstable, difficult to store, or not easily absorbed by the skin

Method used

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  • Cell-penetrating peptide/phospholipid polymer modified liposome emulsion suitable for eye skin as well as preparation and application of cell-penetrating peptide/phospholipid polymer modified liposome emulsion
  • Cell-penetrating peptide/phospholipid polymer modified liposome emulsion suitable for eye skin as well as preparation and application of cell-penetrating peptide/phospholipid polymer modified liposome emulsion
  • Cell-penetrating peptide/phospholipid polymer modified liposome emulsion suitable for eye skin as well as preparation and application of cell-penetrating peptide/phospholipid polymer modified liposome emulsion

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0075] In terms of mass percentage, the raw material composition of the cell-penetrating peptide / phospholipid polymer-modified liposome emulsion suitable for eye skin of this embodiment includes: 20% of liposomes modified with cell-penetrating peptide / phospholipid polymer , Taurine 0.1%, Laurea Azone 0.25%, Propylene Glycol 0.25%, Water 79.4%.

[0076] In terms of mass percentage, the raw material composition of the cell-penetrating peptide / phospholipid polymer-modified liposome includes: hydrogenated soybean phospholipid 30%, cell-penetrating peptide material 2.5%, phospholipid polymer 0.7%, catechin 0.3% %, vitamin B120.1%, vitamin A 0.3%, flaxseed oil 0.5%, cholesterol 4.7%, DSPE-PEG2000 2.3%, water 58.6%.

[0077] The preparation process of the cell-penetrating peptide material is as follows: Weigh 50 mg of DSPE-PEG2000-NHS and 35 mg of TAT with 10 mL of deionized water at room temperature to dissolve completely, and stir and mix at room temperature for 6 hours; the mixed ...

Embodiment 2

[0086] In terms of mass percentage, the raw material composition of the cell-penetrating peptide / phospholipid polymer-modified liposome emulsion suitable for eye skin of this embodiment includes: 30% of liposomes modified with cell-penetrating peptide / phospholipid polymer , L-Potassium Aspartate 1%, Limonene 1.7%, Propylene Glycol 0.9%, Water 66.4%.

[0087] In terms of mass percentage, the raw material composition of the cell-penetrating peptide / phospholipid polymer-modified liposome includes: sphingomyelin 28.2%, cell-penetrating peptide material 2.5%, phospholipid polymer 0.7%, catechin 0.75% %, vitamin B120.25%, vitamin A 0.75%, flaxseed oil 1.25%, cholesterol 5.1%, DSPE-PEG2000 1.9%, water 58.6%.

[0088] The preparation process of the cell-penetrating peptide material is as follows: Weigh 50 mg of DSPE-PEG2000-NHS and 39 mg of R11 with 10 mL of deionized water at room temperature to dissolve completely, and stir and mix at room temperature for 6 hours; the mixed reaction...

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Abstract

The invention discloses a cell-penetrating peptide / phospholipid polymer modified lipidosome emulsion suitable for eye skin, a preparation method of the lipidosome emulsion and application of the lipidosome emulsion in preparation of skin care products. The liposome emulsion is prepared from the following raw materials in percentage by mass: 20%-30% of liposome modified by a cell-penetrating peptide / phospholipid polymer, 0.1%-1% of an excipient, 0.5%-3% of a transdermal absorption enhancer and 66%-79.4% of water. The preparation method comprises the following steps: dissolving lipoid, a cell-penetrating peptide material, a phospholipid polymer and a regulator in a solvent, adding a transdermal absorption enhancer to obtain a solution A, adding an active component into the solution A, fully dissolving the active component, and removing the solvent to obtain a film; and uniformly mixing an excipient and water, mixing with the thin film, fully dissolving the thin film, and carrying out high-pressure homogenization treatment to obtain the liposome emulsion.

Description

technical field [0001] The invention relates to the technical field of liposomes, in particular to a cell-penetrating peptide / phospholipid polymer-modified liposome emulsion suitable for ocular skin and its preparation and application. Background technique [0002] At present, with the emphasis on skin care, the efficacy of skin care products is increasingly pursuing regeneration and health effects. [0003] The skin around the eyes is the thinnest part of the human skin, only 1 / 4 of the thickness of the facial skin, so it is more fragile and more vulnerable to external damage. [0004] There are almost no sebaceous glands and sweat glands under the skin of the eyes, and the oil that can be supplied is relatively much less, which makes the skin of the eyes easy to age and cause wrinkles. Eye discomfort caused by various reasons such as dark circles, eye bags, and inflammation, eye trauma, and vascular lesions. [0005] The key point of skin care design is the basal layer o...

Claims

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Application Information

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IPC IPC(8): A61K8/14A61K8/49A61K8/63A61K8/64A61K8/67A61K8/86A61K8/92A61Q19/00A61Q19/08C08F130/02
CPCA61K8/14A61K8/64A61K8/86A61K8/63A61K8/498A61K8/673A61K8/671A61K8/922A61Q19/005A61Q19/08C08F130/02A61K2800/56A61K2800/57C08F2438/01Y02A50/30
Inventor 李骏汤小苏
Owner HANGZHOU NUOSHEN TECH CO LTD
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