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Hydroxymatatairesinol in cancer prevention

A technology of hydroxyurinol and resin phenol, applied in the prevention of human cancer or some non-cancer hormone-dependent diseases, can solve the problem of increasing lignans, increasing cellulose-rich foods, and the mechanism of action cannot be completely described as hormones, etc. question

Inactive Publication Date: 2004-04-21
HORMOS NUTRACEUTICAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Collectively, these studies suggest that lignans may have weak hormonal (estrogenic and antiestrogenic) effects, but the mechanism of action cannot be fully described as hormonal
[0012] In conclusion, isolated mammalian lignans have not previously been available in sufficient quantities for animal or clinical trials, and the only possibility to increase lignan intake is to increase the intake of cellulose-rich foods such as flaxseed

Method used

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  • Hydroxymatatairesinol in cancer prevention
  • Hydroxymatatairesinol in cancer prevention
  • Hydroxymatatairesinol in cancer prevention

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Experimental program
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Embodiment Construction

[0088] Table 1

[0089] Mammalian lignan production by in vitro fermentation of different plant foods with human fecal flora

[0090] μg / 100g

[0091] Flax meal 68000

[0092] soybeans 170

[0093] Bran:

[0094] Wheat 570

[0095] Oatmeal 650

[0096] Whole grains:

[0097] Rye 160

[0098] potato 80

[0099] Carrot 350

[0100] onion 110

[0101] 1 Thompson et al Nutrition and Cancer 16:43-52, 1991

[0102] Table 2

[0103] Lipid peroxidation inhibition assay to determine the in vitro antioxidant properties of lignans and some related flavonoids

[0104] sex

[0105] compound antioxidant capacity

[0106] (t-BuOOH-LP)

[0107] IC 50 (μM)

[0108] flavonoids

[0109] Camphenol

[0110] (3,4’,5,7-Tetrahydroxyflavone) 0.9

[0111] quercetin

[0112] (3,3’,4’,5,7-pentahydroxyflavone) 0.4

[0113] Campheri...

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Abstract

This invention relates to methods for prevention of cancers, certain non-cancer, hormone dependent diseases and / or cardiovascular diseases in a person, based on administering of hydroxymatairesinol to said person. The invention also concerns a method for increasing the level of enterolactone or another metabolite of hydroxymatairesinol in a person's serum thereby causing prevention of a cancer or a certain non-cancer, hormone dependent disease in a person, based on administering of hydroxymatairesinol to said person. Furthermore, this invention relates to pharmaceutical preparations, food additives and food products comprising hydroxymatairesinol.

Description

technical field [0001] The present invention relates to a method for the prevention of human cancers, certain non-cancer hormone-dependent diseases and / or cardiovascular diseases, which method is based on administering to said patient hydroxyungaucinol. The present invention also relates to a method for preventing human cancer or certain non-cancer hormone-dependent diseases by increasing the level of enterolactone or other hydroxy outai resinol metabolites in the serum of said patient, which method is based on administering to said patient hydroxy Utai resinol. Furthermore, the present invention relates to pharmaceutical preparations, food additives and food products containing hydroxy outai resinol. Background technique [0002] The publications and other materials used herein to illuminate the background of the invention, particularly the cases which provide additional detail regarding the practice of the invention, are hereby incorporated by referenc...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/341A23L1/30A23L3/00A61K31/34A61K31/365A61P1/00A61P5/00A61P13/02A61P13/08A61P13/10A61P15/00A61P25/00A61P35/00A61P39/06C07D307/33
CPCA23L1/3002A23V2002/00A61K31/365A23L33/105A61P1/00A61P13/00A61P13/02A61P13/08A61P13/10A61P15/00A61P15/08A61P25/00A61P35/00A61P39/06A61P43/00A61P5/00A61P5/30A61P5/32A61P9/00A61P9/10A23V2250/2132A61K31/341
Inventor M·奥图帕C·埃克尔曼L·坎加斯S·梅克莱N·萨尔里宁R·桑蒂A·维里
Owner HORMOS NUTRACEUTICAL
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