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Medicinal preparation for assisting in stopping vomiting and preparation process thereof

A pharmaceutical preparation and antiemetic technology, which is applied in the field of omeprazole preparation in the treatment of stomach diseases and auxiliary treatment of vomiting, can solve the problems of low dissolution rate, and achieve the goal of reducing the content of related substances, increasing dissolution rate and improving stability Effect

Active Publication Date: 2022-07-05
SHANDONG NEWTIME PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Overcoming the deficiencies of the prior art, the present invention provides a pharmaceutical preparation for assisting antiemesis and its preparation process, using omeprazole and Radix Ophiopogon japonicus extract in combination to achieve a synergistic effect. By optimizing the disintegration agent and filler, which solves the problem of low dissolution rate caused by insoluble omeprazole and improves the stability of the preparation

Method used

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  • Medicinal preparation for assisting in stopping vomiting and preparation process thereof
  • Medicinal preparation for assisting in stopping vomiting and preparation process thereof
  • Medicinal preparation for assisting in stopping vomiting and preparation process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Example 1 (1000 omeprazole enteric-coated tablets)

[0039]

[0040] Preparation method: dry granulation is adopted, the formula amounts of omeprazole, Ophiopogon japonicus extract, filler, disintegrant, lubricant, and binder are respectively crushed, sieved, mixed, and compressed into tablets. The plain tablet is enteric-coated, that is, it is obtained.

Embodiment 2

[0041] Example 2 (1000 omeprazole enteric-coated capsules)

[0042]

[0043] Preparation method: take an appropriate amount of water as a wetting agent, pulverize and sieve the omeprazole, Ophiopogon japonicus extract, filler, disintegrating agent, lubricant, and binder in the prescribed amount, respectively, and pour into the wet mixing system. In a granulator, stirring, wet granules are obtained, enteric-coated, and put into capsules.

Embodiment 3

[0044] Example 3 (1000 omeprazole enteric-coated tablets)

[0045]

[0046] Preparation method: dry granulation is adopted, the formula amounts of omeprazole, Ophiopogon japonicus extract, filler, disintegrant, lubricant, and binder are respectively crushed, sieved, mixed, and compressed into tablets. The plain tablet is enteric-coated, that is, it is obtained.

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Abstract

The invention belongs to the field of medicinal preparations, and particularly relates to a medicinal preparation for assisting in stopping vomiting and a preparation process thereof, and the medicinal preparation comprises omeprazole, a radix ophiopogonis extract and pharmaceutically acceptable auxiliary materials. The omeprazole and the radix ophiopogonis extract are combined to play a synergistic effect, in addition, by optimizing the disintegrating agent and the filling agent, the problem of low dissolution rate caused by indissolvable omeprazole is solved, and the stability of the preparation is improved.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, relates to an auxiliary antiemetic pharmaceutical preparation and a preparation process thereof, in particular to the use and preparation technology of an omeprazole preparation in the treatment of gastric diseases and auxiliary treatment of vomiting. Background technique [0002] Omeprazole is mainly used for duodenal ulcer and Zollinger-Ellison syndrome, and can also be used for gastric ulcer and reflux esophagitis; intravenous injection can be used for the treatment of acute bleeding of peptic ulcer. The gastric acid proton pump on the surface, which inhibits the last channel of gastric acid secretion, has a strong and lasting inhibitory effect on gastric acid secretion stimulated in various ways and even basal acid secretion. Omeprazole can not only accelerate the healing of duodenal ulcer (DU) and gastric ulcer (GU), shorten the course of treatment by 2-4 weeks, but also relieve sy...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4439A61K36/8968A61K9/20A61K47/38A61K47/36A61K47/10A61K47/02A61P1/08A61P1/04A61K31/352
CPCA61K31/4439A61K36/8968A61K9/2054A61K9/205A61K9/2018A61K9/2009A61K9/282A61P1/08A61P1/04A61K31/352A61K2300/00
Inventor 刘奎元刘金耿
Owner SHANDONG NEWTIME PHARMA