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Application of lamotrigine in medicine for treating thyroid dysfunction diseases

A technology of thyroid function and lamotrigine, which is applied in the field of medicine and can solve problems such as adverse reactions, difficulty in treating abnormal thyroid function, and treating the symptoms but not the root cause

Pending Publication Date: 2022-07-05
WEST CHINA HOSPITAL SICHUAN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

That is to say, the current drugs for the treatment of abnormal thyroid function need to be taken by patients for a long time or even for life. The treatment plan is mainly to control the related hormones within the normal range. The effect of the disease, and the side effects and adverse reactions caused by long-term use of drugs have also brought a lot of trouble to patients
At the same time, for patients with underlying diseases (such as diabetes and other disorders of glucose metabolism), once abnormal thyroid function occurs at the same time, the drug used for the treatment of the basic disease and the drug that regulates thyroid hormones should not be used. It is also difficult to predict whether the effects will affect each other, which brings greater difficulty to the treatment of abnormal thyroid function.

Method used

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  • Application of lamotrigine in medicine for treating thyroid dysfunction diseases
  • Application of lamotrigine in medicine for treating thyroid dysfunction diseases

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0022] Experimental Example 1. Therapeutic effect of lamotrigine on patients with thyroid dysfunction

[0023] 1. Experimental method

[0024] 1.1 Case inclusion criteria: A total of 966 patients with abnormal glucose metabolism (including patients with type 2 diabetes mellitus, impaired glucose tolerance and impaired fasting blood glucose) and those with abnormal hypothalamic-pituitary-thyroid axis function were treated at West China Hospital of Sichuan University. .

[0025] Criteria for dysfunction of the hypothalamic-pituitary-thyroid axis (HPT axis):

[0026] Detect the patient's HPT axis indicators: TSH, FT4, FT3, TT4, TT3. Referring to the Laboratory Department of West China Hospital, Sichuan University, the normal ranges of hormones are as follows: TSH: 0.27-4.2mU / L, TT3: 1.3-3.1nmol / L, FT3: 3.6-7.5pmol / L, TT4: 62-164nmol / L, FT4: 12-22pmol / L, ACTH: 5.0-78ng / L, COR (8:00 am): 147.3-609.3nmol / L; range above or below the reference value was defined as "abnormal". The ...

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Abstract

The invention provides a new application of lamotrigine in a medicine for treating thyroid dysfunction diseases. Lamotrigine can treat thyroid dysfunction and promote thyroid function indexes to recover to a normal range; on one hand, the lamotrigine is good in safety, and even if the lamotrigine is taken for a long time, the lamotrigine does not cause adverse reaction or thyroid damage like an anti-hyperthyroidism medicine, so that the lifelong hypothyroidism is More importantly, lamotrigine can cure abnormal onychomycosis, so that a patient can be cured and the drug is stopped, and thyroxine is not required to be used for the lifetime like conventional hypothyroidism treatment. Even for patients who suffer from basic diseases (such as diabetes) and simultaneously suffer from thyroidism, the regulating and improving effects of lamotrigine on thyroidism are not obviously influenced by drugs for treating basic diseases, and the patients can take the drugs at the same time, so that the treatment effect of lamotrigine on thyroidism is greatly improved, and the treatment effect of lamotrigine on thyroidism is improved. And the effects of treating abnormal nail function and finally stopping medicine taking can be achieved.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the use of lamotrigine in a medicine for treating abnormal thyroid function diseases. Background technique [0002] The thyroid gland is the largest endocrine gland in the human body, and it mainly synthesizes and secretes thyroxine. Thyroid dysfunction diseases are diseases with too much or too little thyroid hormone secretion, which are beyond the normal range. According to the amount of thyroid hormone secretion, it is divided into hyperthyroidism and hyperthyroidism. Hypothyroidism. Among them, hyperthyroidism is characterized by the increase of thyroid hormones in the blood circulation. If not treated in time, it will cause hyperthyroid heart disease, lead to heart failure, arrhythmia, and even affect life. Hyperthyroidism can also cause electrolyte abnormalities in patients, resulting in hypokalemic periodic paralysis, which seriously affects the quality of life and lif...

Claims

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Application Information

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IPC IPC(8): A61K31/53A61P5/16A61P5/14
CPCA61K31/53A61P5/16A61P5/14
Inventor 李佳琦孙学礼
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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