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Luminescent imaging for sensing

An imaging device and image technology, which can be used in luminescent materials, record carriers used in machines, sensors, etc., and can solve problems such as limited methods

Pending Publication Date: 2022-07-12
C2SENSE INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although smartphones have recently been used to provide high-resolution image acquisition and analysis, these methods are still limited

Method used

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  • Luminescent imaging for sensing
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Examples

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Effect test

example 1

[0681] Example 1 - Direct Capture System

[0682] Human IgG was bound to 200 nm europium (Eu) beads, and goat anti-human IgG / IgM was immobilized on nitrocellulose. The lateral flow device including the pretreated fiberglass sample pad and cover tape was then assembled. Dilutions of Eu-tagged human IgG in buffer were deposited on the sample / binding pad of the lateral flow device and developed by immersion in buffer. Imaging / analyzing chromatographic results after a set time has elapsed using a customized smartphone device, holder and algorithm / app ( Figure 8 ).

example 2

[0683] Example 2 - Serological Detection System - Antibody Detection

[0684] Chicken IgY (control line), goat anti-human IgA (test line 1), donkey anti-human IgM (test line 2) and donkey anti-human IgG (test line 3) were immobilized on the assembled nitrocellulose and lateral flow device . Eu-tagged donkey anti-chicken and Eu-tagged mouse anti-HIS are then deposited on the sample / binding pad, followed by placement of specific COVID-19 antigens, such as HIS-tagged nucleoprotein (NP) antigens. The resulting device was then tested using clinically derived human COVID-19 antibody positive and negative saliva or blood / serum samples and imaged / analyzed using a custom-made smartphone device, scaffold, and algorithms / apps. Figure 9 An example of a negative assay where only the control line was detected is shown. Figure 10 An example of a positive assay that detects an IgG line in addition to the control line is shown.

example 3

[0685] Example 3 - Sandwich Assay System - Antigen Detection

[0686] The coronavirus NP capture antibody was immobilized on nitrocellulose and the assembled lateral flow device. The coronavirus COVID-19 SARS NP detection antibody conjugated to 200nm Eu beads was mixed with the coronavirus COVID-19 NP antigen in buffer or human saliva, and the assay was developed. The results are then imaged / analyzed using a customized smartphone device, mount and algorithm / app. Figure 11 An example of a negative assay with no line detected is shown. Figure 12 An example of a positive assay where a line was detected is shown.

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Abstract

Embodiments described herein generally relate to sensing and / or authentication using luminescence imaging; diagnostic assays, systems, and related methods; temporal thermal sensing and related methods; and / or emitters, such as emitters that can be excited by white light, and related systems and methods.

Description

[0001] Related applications [0002] This application claims priority under 35 U.S.C. §119(e): US Provisional Patent Application No. 63 / 085,929, filed September 30, 2020, entitled "WHITELIGHT EMISSIVE SPECIES AND RELATED METHODS," August 24, 2020 U.S. Provisional Patent Application No. 63 / 069,544, entitled "DIAGNOSTIC ASSAYS AND RELATED METHODS," filed on July 20, 2020 , and U.S. Provisional Patent Application No. 62 / 916,331, entitled "LUMINESCENCE IMAGING FOR SENSING AND / OR AUTHENTICATION," filed October 17, 2019, the contents of each of which are hereby incorporated by reference in their entirety for all purposes Purpose. technical field [0003] Embodiments described herein generally relate to: sensing and / or authentication using luminescence imaging; diagnostic assays, systems, and related methods; temporal thermal sensing and related methods; and / or emitting species such as those excitable by white light Classes and related systems and methods. Background technique ...

Claims

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Application Information

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IPC IPC(8): G01N21/64G01N21/76B44F1/08G06V10/141G06V10/143
CPCC09K11/06G01J3/0272G01J3/2803G01J3/443G01N21/6408G01N21/76G01N21/251G01N21/6456G01N2021/6417Y02B20/00G06V10/141G06V10/143H10K50/11H10K2101/20G01N2021/6413G01N2201/0221G01N21/6428G01N21/645G01N21/21G01N33/56983G01N33/582G01J5/02G06V20/80G06V40/1318G06K19/14A61B5/0077A61B5/117H04N5/33G01N2021/6432G01N2021/6439G01N2021/6441G01N2021/6471G01N2021/757G01N2201/062G01N2333/165G01J2005/0077C09K2211/1007C09K2211/1029C09K2211/1044C09K2211/1059C09K2211/1092C09K2211/182H04N25/53H04N25/76G01N33/54388G01N33/54391H10K2101/10G01N21/00G01N33/54386G01N21/63G06V10/00
Inventor 蒂莫西·曼宁·斯韦格罗伯特·迪恩斯詹森·R·科克斯杰弗里·N·塔科勒加百利·戴维斯安德鲁·惠勒史蒂文·R·弗莱彻朱正国布赖恩·E·弗拉托安德鲁·纳尔逊
Owner C2SENSE INC
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