Luteolin-autism related action gene target and screening method thereof

A technology of luteolin and screening methods, applied in genomics, biochemical equipment and methods, pharmaceutical formulations, etc., can solve problems such as unclear targets and mechanisms, achieve rich development and industrialization, and narrow the scope of research and development of new drugs , the effect of improving efficiency

Pending Publication Date: 2022-07-22
FOURTH MILITARY MEDICAL UNIVERSITY
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Problems solved by technology

Luteolin is a flavonoid compound with various pharmacological activities. It is the main active ingredient of lotus seed heart. , but its target and mechanism are still unclear

Method used

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  • Luteolin-autism related action gene target and screening method thereof
  • Luteolin-autism related action gene target and screening method thereof
  • Luteolin-autism related action gene target and screening method thereof

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Embodiment Construction

[0036] In order to make the objectives, technical solutions and advantages of the present invention clearer and clearer, the present invention will be further illustrated and described below through specific embodiments in conjunction with the accompanying drawings.

[0037] A screening method for luteolin-autism-related gene targets, comprising the following operations:

[0038] S1. Screening of the action targets of active ingredients, and screened out the action targets of luteolin;

[0039] S2, disease candidate target identification

[0040] In disease target databases (DisGeNET, Genecard and Omim), search for autism candidate targets with "Autism" as the keyword. Then, perform intersection mapping with the component action target obtained by S1 to obtain the component-disease intersection target gene, that is, the action target of luteolin in the treatment of autism.

[0041] S3. Construct component target-disease target network and screen core targets

[0042] The ST...

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Abstract

The invention belongs to the field of biomedicine, and discloses a luteolin-autism related action gene target and a screening method thereof. According to the invention, a luteolin pharmacological target and an autism related target are obtained through online database analysis such as TCMSP, DisGeNET and the like; taking an intersection of luteolin and autism target spots to obtain a drug disease intersection target gene target spot, and constructing a related protein interaction network to screen a core target spot; further performing gene ontology GO biological process and KEGG pathway enrichment analysis on the core target; the range of new drug research and development is narrowed, the research and development purpose is accurate, and the drug research and development cost is saved; meanwhile, the medicine screening and predicting efficiency is greatly improved, and breakthrough significance is achieved for development and industrialization of rich traditional Chinese medicine resources in China.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a luteolin-autism-related gene target and a screening method thereof. Background technique [0002] Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by language, social interaction, and repetitive movements. In recent years, research reports have shown that the incidence of ASD has gradually increased. According to the US Centers for Disease Control and Prevention, the prevalence rate in 2018 was 1 / 59, an increase of 16% compared with 2014. However, because the etiology and pathological mechanism of ASD is still unclear, there is no clear drug or surgical treatment method, which brings great mental pressure and economic burden to families and individuals. However, there is still a lack of clear diagnosis, prevention and treatment plans for autism in clinical practice. Therefore, exploring the pathogenesis of autism, seeking practical and effective treatme...

Claims

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Application Information

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IPC IPC(8): G16B50/30G16B20/00C12Q1/6883A61P25/00A61K45/00
CPCG16B50/30G16B20/00C12Q1/6883A61K45/00A61P25/00C12Q2600/136
Inventor 杨奇张梦佳于娇妍刘庆庆
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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