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Aqueous humor drainage device implanted into eye and preparation method of aqueous humor drainage device

An aqueous humor and drainage channel technology, which is applied to the aqueous drainage device implanted in the eye and the field of its preparation, can solve problems such as instability and easy movement, achieve good effects, avoid displacement after implantation, and increase waterproof drainage. The effect of efficiency

Pending Publication Date: 2022-07-29
天宸(天津)生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the drainage implants in the prior art are usually unstable and easy to move after being implanted into the schlemm canal

Method used

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  • Aqueous humor drainage device implanted into eye and preparation method of aqueous humor drainage device
  • Aqueous humor drainage device implanted into eye and preparation method of aqueous humor drainage device

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] (1) Mix the powdered solid animal-derived gelatin with a solvent, the solvent is a mixture of N,N-dimethylformamide and formic acid, and the volume ratio of N,N-dimethylformamide and formic acid is 1:5 , and then placed in a 50 ℃ water bath for stirring and dissolving until the solid gelatin melted into liquid gelatin;

[0029] (2) reducing the temperature of the liquid gelatin to 40°C, then adding glutaraldehyde and stirring, the volume ratio of the glutaraldehyde and the liquid gelatin is 5:100, after fully mixing, keep this temperature for crosslinking for 18h;

[0030] (3) After the cross-linking is completed, inject the mixed liquid through the injection port of the microfluidic chip, and after the liquid gelatin is injected, put the microfluidic chip into the alkaline coagulation solution at 5 °C, and the alkaline The coagulation liquid is NaOH, which is taken out after coagulation and demoulded;

[0031] (4) washing the obtained tubular product with distilled wa...

Embodiment 2

[0037] (1) Mix the powdered solid animal-derived gelatin with a solvent, the solvent is a mixture of N,N-dimethylformamide and formic acid, and the volume ratio of N,N-dimethylformamide and formic acid is 1:5 , and then placed in a 50 ℃ water bath for stirring and dissolving until the solid gelatin melted into liquid gelatin;

[0038] (2) reducing the temperature of the liquid gelatin to 40°C, then adding glutaraldehyde and stirring, the volume ratio of the glutaraldehyde and the liquid gelatin is 5:100, after fully mixing, keep this temperature for crosslinking for 18h;

[0039] (3) After the cross-linking is completed, inject the mixed liquid through the injection port of the microfluidic chip, and after the liquid gelatin is injected, put the microfluidic chip into the alkaline coagulation solution at 5 °C, and the alkaline The coagulation liquid is NaOH, which is taken out after coagulation and demoulded;

[0040] (4) washing the obtained tubular product with distilled wa...

Embodiment 3

[0046] (1) Mix the powdered solid animal-derived gelatin with a solvent, the solvent is a mixture of N,N-dimethylformamide and formic acid, and the volume ratio of N,N-dimethylformamide and formic acid is 1:5 , and then placed in a 50°C water bath for stirring and dissolving until the solid gelatin melted into liquid gelatin;

[0047] (2) reducing the temperature of the liquid gelatin to 40°C, then adding glutaraldehyde and stirring, the volume ratio of the glutaraldehyde and the liquid gelatin is 5:100, after fully mixing, keep this temperature for crosslinking for 18h;

[0048] (3) After the cross-linking is completed, inject the mixed liquid through the injection port of the microfluidic chip, and after the liquid gelatin is injected, put the microfluidic chip into the alkaline coagulation solution at 5 °C, and the alkaline The coagulation liquid is NaOH, which is taken out after coagulation and demoulded;

[0049] (4) washing the obtained tubular product with distilled wa...

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PUM

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Abstract

The aqueous humor drainage device comprises a drainage straight pipe, a drainage channel is formed in the middle of the drainage straight pipe, a plurality of evenly-distributed through holes are symmetrically formed in the two ends of the drainage straight pipe, and grid plates are arranged in the through holes. A spiral protrusion is arranged between the two sets of through holes, a sustained-release film is arranged between every two adjacent through holes in the same horizontal line, and medicine is stored in the sustained-release films. According to the aqueous humor drainage device implanted into the eye and the preparation method of the aqueous humor drainage device, the prepared drainage straight pipe avoids the blockage problem of the drainage pipe, the waterproof drainage efficiency is improved, an auxiliary fixing structure is additionally arranged, so that displacement after implantation is avoided, and the long-term treatment effect is good.

Description

technical field [0001] The invention relates to the technical field of ophthalmic medical devices, in particular to an aqueous humor drainage device implanted in the eye and a preparation method thereof. Background technique [0002] Glaucoma is a group of diseases characterized by atrophy and depression of the optic nerve head, visual field defect and vision loss. Sex is also associated with the development and progression of glaucoma. Any obstruction in the aqueous humor circulation pathway can lead to pathological changes caused by elevated intraocular pressure, but some patients also present with normal intraocular pressure glaucoma. Glaucoma is one of the three major blindness diseases that cause blindness in humans, with an incidence of 1% in the general population and 2% after the age of 45. Clinically, glaucoma is divided into three categories: primary, secondary and congenital according to the etiology, angle of the chamber, intraocular pressure and other conditio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F9/007
CPCA61F9/00781
Inventor 吴莹倪力
Owner 天宸(天津)生物科技有限公司