Mixed solubilizer and preparation method thereof
A kind of solubilizing agent and mixed-type technology, which is applied in the field of mixed-type solubilizing agent and its preparation, can solve the problems that the solubilization effect of cannabidiol is difficult to achieve, and achieve the effects of large solubilization adaptability, improved efficiency, and avoiding data screening
Pending Publication Date: 2022-07-29
云南比昂汉普生物科技有限公司
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Problems solved by technology
[0013] The purpose of the present invention is to provide a mixed solubilizer and its preparation method to solve the technical problem that a single solubilizer in the prior art is difficult to achieve a solubilizing effect on cannabidiol
Method used
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Effect test
Embodiment 1
[0035] The solvent, emulsifier and solubilizer are loaded into the sterilized stainless steel container according to the ratio in Table 1, and the rotating speed is 600 rev / min for continuous stirring for 30min. solvent.
Embodiment 2
[0037] The solvent, emulsifier and solubilizer are loaded into the sterilized stainless steel container according to the ratio in Table 1, and the rotating speed is 550 rev / min for continuous stirring for 35min. solvent.
Embodiment 3
[0039] The solvent, emulsifier and solubilizer are loaded into the sterilized stainless steel container according to the ratio in Table 1, and the rotating speed is 650 rpm / min for continuous stirring for 25min. solvent.
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The invention discloses a mixed type solubilizer and a preparation method thereof, and solves the technical problem that a solubilizing effect of a single solubilizer on cannabidiol is difficult to achieve in the prior art. The mixed solubilizer comprises the following raw materials in parts by weight: 45-55 parts of a solvent; 15 to 25 parts of an emulsifier; and 25-35 parts of a solubilizer. The mixed solubilizer has an obvious solubilizing effect on an insoluble new molecular entity cannabidiol, also has an obvious solubilizing effect on other insoluble drugs (such as ibuprofen and vitamin E), is wide in solubilizing application range, and can be used for preparing a medicine for preventing and treating diseases. The process of screening a large amount of experimental data, wasting labor and time and tedious operation can be avoided, the efficiency is improved, the research and development cost of the indissolvable drugs is reduced, and the research and development and later clinical experiment processes of the indissolvable drugs are greatly shortened.
Description
technical field [0001] The invention relates to a solubilizer for an insoluble bulk drug and an insoluble new molecular entity substance, in particular to a mixed-type solubilizer and a preparation method thereof. Background technique [0002] Solubilization refers to the process in which poorly soluble drugs increase their solubility in a solvent and form a solution under the action of surfactants. The process of increasing the solubility of a poorly soluble drug and forming a clear solution in the presence of colloidal particles of surfactant is called solubilization. The surfactant used for solubilization is called solubilizer. For example, the solubility of cresol in water is only about 3%, but it can increase by 50% in soap solution (ie cresol soap solution). The soap here is Solubilizers. Substances that are solubilized are called solubilizers. For drugs with water as solvent, the optimum HLB value of the solubilizer is 15-18. Commonly used solubilizers are polysor...
Claims
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Patent Timeline
Login to View More IPC IPC(8): A61K47/44A61K47/14A61K47/10A61K47/12A61K47/26A61K47/24A61K47/22A61K47/18A61K31/05A61K31/192A61K31/355
CPCA61K47/44A61K47/14A61K47/10A61K47/12A61K47/26A61K47/24A61K47/22A61K47/18A61K31/05A61K31/192A61K31/355
Inventor 张少伟辛荣昆杨凯衡
Owner 云南比昂汉普生物科技有限公司