Derivatization reagent, kit and method for detecting nerve agent

A neurological, kit-based technology, applied in the field of analytical chemistry, can solve the problems of weak characteristic signal, high detection limit, and difficulty in accurately measuring the content of toxic agents.

Pending Publication Date: 2022-08-09
ACADEMY OF MILITARY MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the simple molecular structure, small Raman interface and weak characteristic signal of most nerve agents, the sensitivity and detection limit of most nerve agents are poor when they are directly detected by SERS.
[0005] In addition, in the aqueous environment, the P-F or P-CN bonds contained in NAs are easily hydrolyzed, resulting in a further reduction in detection sensitivity, and the degradation rate of NAs contained in biological samples is faster due to their more complex matrix, This makes it difficult to accurately measure the amount of toxic agent in the sample

Method used

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  • Derivatization reagent, kit and method for detecting nerve agent
  • Derivatization reagent, kit and method for detecting nerve agent
  • Derivatization reagent, kit and method for detecting nerve agent

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Experimental program
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Embodiment Construction

[0018] Compounds of formula I

[0019] The compound shown in the formula I of the present invention can be used as the derivatization reagent of the nerve agent to detect the nerve agent in the sample, and its structural formula is as follows:

[0020]

[0021] where R 1 and R 2 independently C 1-4 Alkyl, or R 1 and R 2 The N atoms to which they are attached form nitrogen-containing heterocycles or nitrogen-containing heteroaromatic rings.

[0022] In certain embodiments, R 1 and R 2 independently C 1-4 Alkyl, or R 1 and R 2 The N atoms to which they are attached form five- or six-membered nitrogen-containing heterocycles or nitrogen-containing heteroaromatic rings.

[0023] In certain embodiments, R 1 and R 2 Each is independently methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl or tert-butyl.

[0024] In certain embodiments, R 1 and R 2 Each is independently methyl, ethyl or n-propyl.

[0025] In certain embodiments, R 1 and R 2 Each is ...

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Abstract

The invention relates to an application of a compound shown in a formula I for detecting a nerve agent in a sample, relates to a kit containing the compound shown in the formula I, further relates to an application of the kit for detecting the nerve agent in the sample, and further relates to a method for detecting the nerve agent in the sample.

Description

technical field [0001] The invention belongs to the field of analytical chemistry, and relates to the use of a compound shown in formula I for detecting neurotoxic agents in a sample, a kit comprising the compound shown in formula I, and the use of the kit for detecting a sample in a sample The use of the nerve agent also relates to a method for detecting the nerve agent in a sample. Background technique [0002] Nerve agents (NAs) are a class of quick-killing agents in Schedule 1 of the Chemical Weapons List that can be easily expanded in structure, and the number of types can be expanded to tens of thousands or even hundreds of thousands. However, the most studied are still Sarin (GB), Tabun (GA), Soman (GD) and Viex (VX) and other classic warfare agents, commonly known as the "four masters" of nerve agents. The reason lies in its low lethal dose, fast enzyme inhibition rate, and difficulty in reactivation. The mechanism of its toxicity is clear, that is, after exposure ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/65C07D213/65
CPCG01N21/658C07D213/65
Inventor 吴剑峰谢剑炜谢斯哲李楠楠刘玉龙李泽华
Owner ACADEMY OF MILITARY MEDICAL SCI
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