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Application of fur seal oil in preparation of medicine for treating lipometabolism disorder

A technology for lipid metabolism disorder and seal oil, which is applied in the application field of seal oil in the preparation of a drug for treating lipid metabolism disorder

Inactive Publication Date: 2005-04-20
中国生化制药工业协会
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, there are no specific animal experiments or clinical results to prove

Method used

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  • Application of fur seal oil in preparation of medicine for treating lipometabolism disorder
  • Application of fur seal oil in preparation of medicine for treating lipometabolism disorder
  • Application of fur seal oil in preparation of medicine for treating lipometabolism disorder

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0039] This experimental example adopts high-fat feed to cause the rat lipid metabolism disorder model to test the effect of seal oil of the present invention on rat lipid metabolism disorder, and to the drug effect of seal oil by continuous gavage for two weeks at a dose of 2.2ml / KG The results showed that the drug can significantly reduce the levels of total cholesterol (TC) and triglyceride (TG) in rat serum, significantly increase the level of HDL, and significantly decrease the level of LDL+VLDL, and make the levels of cholesterol in liver tissue significantly lower. The level decreased significantly, indicating that the drug has obvious effects of lowering blood fat and reducing liver fat.

[0040] experiment material:

[0041] (1) Sea dog oil, a yellowish oily liquid extracted from the body of sea dogs, produced by Shan Atlantic Food Company, stored at room temperature in this laboratory, during the test, 1.2ml (the original solution is used in high doses) or 1ml (mediu...

experiment example 2

[0058] This experimental example adopts high-fat feed to cause the disordered lipid metabolism model of rabbits to test the effect of seal oil of the present invention on the disordered lipid metabolism of rabbits. The pharmacodynamic effect of gavage for two weeks was observed, and it was found that the drug can significantly reduce the levels of total cholesterol (TC) and triglyceride (TG) in rabbit serum, significantly increase the level of HDL, and significantly increase the level of LDL+VLDL. Decrease, so that the cholesterol level in the liver tissue decreased significantly, indicating that the drug has obvious effects of lowering blood fat and reducing liver fat.

[0059] The test materials used in this experiment example are as follows:

[0060] (1) Sea dog oil, a slightly yellow oily liquid with a slippery cavity extracted from the body of the sea dog, produced by Shan Atlantic Food Company, stored at room temperature in this laboratory, during the test, 9ml (the orig...

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Abstract

An application of ursine seal's fat to preparing medicines to treat fat metabolism disorder (hyperlipomia) is disclosed. Its advantage is high curative effect on lowering the level of serum cholesterol and triglyceride and increasing that of HDL.

Description

technical field [0001] The present invention relates to the use of seal oil as a drug for the preparation of lipid metabolism disorders (hyperlipidemia). ) application of medicine. Background technique [0002] As we all know, the number of patients with diabetes, liver disease, prostate disease, hyperlipidemia and other diseases is huge, but in practical applications, it is difficult to identify drugs with particularly obvious effects and almost no side effects. [0003] It is generally believed that the number of patients suffering from such diseases among Eskimos and Japanese coastal fishermen is significantly lower than that of the general population. The researchers believe that this phenomenon is related to their consumption of fur seal meat and oil rich in unsaturated fatty acids. [0004] However, so far there is no specific animal experiment or clinical results to prove it. [0005] The fur seal described in the present invention usually refers to a kind of mammal...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/202A61K35/35A61P3/06
Inventor 徐康森李湛军乐嘉静忻余林兰何谓鉴
Owner 中国生化制药工业协会