Immunomodulators

An amino acid, selected technology, applied in the direction of immunoglobulin, anti-blood group antigen immunoglobulin, anti-animal/human immunoglobulin, etc., can solve the problems of delayed disease development, unsatisfactory side effects of treatment, etc.

Inactive Publication Date: 2005-08-31
STEENO RES GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Said treatment is usually unsatisfactory, produces unwanted and often serio

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0181] Embodiment: 1.NH 2 -Ala-Tyr-Met-Thr- Ile -Lys- met -Arg-Asn-COOH (SEQ ID NO: 2)

[0182] 2. NH 2 -Ala- Phe -Met-Thr- Leu -Lys- Leu -Arg-Asn-COOH (SEQ ID NO: 3)

[0183] 3. NH 2 -Ala-Tyr-Met-Thr-Met-Lys- Val -Arg- Glu -COOH (SEQ ID NO: 4)

[0184] 4. NH 2 -Gly-Tyr-Met-Thr-Met-Lys-Ile-Arg-Asp-COOH (SEQ ID NO: 5)

[0185] 5. NH 2 -Ala-Phe-Met-Thr-Met-Lys-Ile-Arg-Asp-COOH (SEQ ID NO: 6)

[0186] 6. NH 2 -Ala-Tyr-Ile-Thr-Met-Lys-Ile-Arg-Asp-COOH (SEQ ID NO: 7)

[0187] 7. NH 2 -Ala-Tyr-Leu-Thr-Met-Lys-Ile-Arg-Asp-COOH (SEQ ID NO: 8)

[0188] 8. NH 2 -Ala-Tyr-Val-Thr-Met-Lys-Ile-Arg-Asp-COOH (SEQ ID NO: 9)

[0189] 9. NH 2 -Ala-Tyr-Met-Thr-Ile-Lys-Ile-Arg-Asp-COOH (SEQ ID NO: 10)

[0190] 10. NH 2 -Ala-Tyr-Met-Thr-Leu-Lys-Ile-Arg-Asp-COOH (SEQ ID NO: 11)

[0191] 11. NH 2 -Ala-Tyr-Met-Thr-Val-Lys-Ile-Arg-Asp-COOH (SEQ ID NO: 12)

[0192] 12. NH 2 -Ala-Tyr-Me...

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PUM

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Abstract

This invention relates to a polypeptide other than human interleukin (10) which has at least one of the following properties: a) induces inhibition of spontaneous IL-8 production by human monocytes, b) induces inhibition of IL-1 beta induced IL-8 production by human peripheral blood mononuclear cells (PBMC), c) induces production of interleukin-1 receptor antagonistic protein (IRAP) by human monocytes, d) induces chemotactic migration of CD8+ human T lymphocytes in vitro, e) desensitizes human CD8+ T cells resulting in an unresponsiveness towards rhIL-10, f) suppresses the chemotactic response of CD4+ T human lymphocytes towards IL-8, g) suppresses the chemotactic response of human monocytes towards MCAF/MCP-1, h) does not inhibit class II MHC molecule expression on human monocytes, in contrast to human IL-10, i) induces the production of IL-4 by cultured normal human CD4+ T cells, j) reduces the TNF alpha production in human mixed leukocyte reaction. In particular, the invention relates to the nonapeptide Ala-Tyr-Met-Thr-Met-Lys-Ile-Arg-Asn and analogues and variants thereof.

Description

field of invention [0001] The present invention relates to a pharmaceutical use of a substance which is an interleukin 10 (IL-10) agonist, in particular to the use of the substance of the present invention in the preparation of a pharmaceutical composition for preventing and / or treating diseases, wherein the pathogenesis involves Reduced production and / or decreased function of immunosuppressive mediators, especially cytokines, and / or involvement of specific immune-inflammatory mediators, especially increased production and / or enhanced function of cytokines. In particular, the present invention relates to the use of the substances of the present invention in the preparation of pharmaceutical compositions for the prevention and / or treatment of autoimmune diseases (type I diabetes; gastrointestinal inflammatory diseases, rheumatoid arthritis), gout Acute (urica) arthritis (gout), skin allergies; skin, lung, and respiratory allergies (including bronchial asthma); tissue damage by ...

Claims

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Application Information

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IPC IPC(8): C12N15/09A61K38/00A61K38/20A61K39/00A61K39/395A61P31/12A61P35/00A61P37/02A61P37/04A61P43/00C07K7/00C07K7/06C07K14/52C07K14/54C07K16/00C07K16/24C12N15/00C12N15/24C12P21/08C12R1/91
CPCA61K38/00C07K14/5428A61K39/00A61P31/12A61P35/00A61P37/02A61P37/04A61P43/00
Inventor C·格龙霍拉森B·杰泽
Owner STEENO RES GROUP
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