Angiosupport made of polyurethane and polyhydroxy fatty acid ester comixture and its preparation method

A technology of polyhydroxyalkanoate and vascular stent, which is applied in the field of biomedical engineering and can solve problems such as no literature reports

Inactive Publication Date: 2005-10-19
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As for how to prepare a degradable polymeric material into a tube first, and then implant it into the body for cell adhesion, there is no literature report yet.

Method used

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  • Angiosupport made of polyurethane and polyhydroxy fatty acid ester comixture and its preparation method
  • Angiosupport made of polyurethane and polyhydroxy fatty acid ester comixture and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Example 1: Preparation of a PHB-HV / PU vascular stent with a diameter of 8 mm and a length of 50 mm

[0035] 1. Preparation of PHB-HV / PU solid film

[0036] ①, Mix PHB-HV and chloroform in a flask, mixing ratio: 1gPHB-HV plus 20ml chloroform, heat in a water bath, reflux for 15 minutes, and prepare a uniform solution. Mix PU and tetrahydrofuran in another flask, mixing ratio: 1gPU plus 20ml tetrahydrofuran, heat in a water bath, reflux for 15 minutes, and prepare a homogeneous solution.

[0037] ② Use a pipette to pipette the PU solution according to the proportion (the mass percentage of PU is 5%), slowly add it dropwise to the PHB-HV solution, stir while adding, condense and reflux for 15 minutes.

[0038] ③, using the method of cast film formation, cool the solution prepared in ② and pour it into a pair of evaporating dishes with a diameter of 10cm, fasten the upper and lower evaporating dishes, and slowly volatilize chloroform and tetrahydrofuran within 2 days , an...

Embodiment 2

[0054] Example 2: Preparation of a PHB / PU vascular stent with a diameter of 3 mm and a length of 10 mm

[0055] 1. Preparation of PHB / PU solid film

[0056] The preparation method is the same as the method for preparing the PHB-HV / PU solid film in Example 1, except that the PHB-HV / PU is replaced by PHB / PU, the percentage of PU is adjusted to 10%, and the diameter of the evaporating dish is adjusted to 6cm.

[0057] 2. Preparation of PHB / PU porous membrane

[0058] The preparation method is the same as the method for preparing the PHB-HV / PU solid film in Example 1, except that the PHB-HV / PU is replaced by PHB / PU, the percentage of PU is adjusted to 10%, and the diameter of the evaporating dish is adjusted to 6cm, the particle size of NaCl is adjusted to 200-300μm.

[0059] 3. Preparation of PHB / PU reinforcement

[0060] The preparation method is the same as the method for preparing the PHB-HV / PU reinforcing rib in Example 1, except that PHB-HV / PU is replaced by PHB / PU.

[...

Embodiment 3

[0063] Example 3: Preparation of a PHB-HH / PU vascular stent with a diameter of 12 mm and a length of 100 mm

[0064] 1. Preparation of PHB-HH / PU solid film

[0065] The preparation method is the same as the method for preparing the PHB-HV / PU solid film in Example 1, except that PHB-HV / PU is replaced by PHB-HH / PU, the percentage of PU is adjusted to 20%, and the diameter of the evaporating dish Adjusted to 19cm.

[0066] 2. Preparation of PHB-HH / PU porous membrane

[0067] The preparation method is the same as the method for preparing the PHB-HV / PU porous membrane in Example 1, except that PHB-HV / PU is replaced by PHB-HH / PU, the percentage of PU is adjusted to 20%, and the diameter of the evaporating dish is adjusted to 20%. Adjust to 19 cm, and adjust the particle diameter of NaCl to 200 to 300 μm.

[0068] 3. Preparation of PHB-HH / PU reinforcement

[0069] The preparation method is the same as the method for preparing the PHB-HV / PU reinforcing rib in Example 1, except tha...

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Abstract

A blood vessel scaffold is prepared from a mixture of polyurethane (PU) and polyhydroxy aliphatic ester (PHA), and is composed of multi-porous tunica intima, solid adventitia and reinforcing ribs. Its advantages are high biocompatibility, anticoagulation and cell adhesion, proper degradation speed, and improved mechanical strength and stitch strength.

Description

technical field [0001] The invention relates to a blood vessel stent made of a blend of polyurethane and polyhydroxyalkanoate, belonging to the field of biomedical engineering. Background technique [0002] 1. Materials used [0003] At present, the main medical method for diseased blood vessels with a diameter of no more than 6 mm is to use autologous blood vessels as a detour bypass to replace diseased blood vessels, but many patients do not have appropriate and sufficient blood vessels for detour bypasses, so synthetic materials are used to prepare blood vessels. Bracket ideas. The basic idea of ​​using blood vessels made of synthetic materials as a detour is to adsorb tissue cells on a scaffold material with good biocompatibility that can be gradually degraded and absorbed in the human body, and provide nutrients to the cells to expand them. While the scaffold material is gradually degraded and absorbed by the human body, the cells continue to proliferate and secrete t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F2/06A61L29/04A61L31/04C08L67/04C08L75/04
Inventor 胡平郇春艳
Owner TSINGHUA UNIV
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