Taxane injecta preparation
A technology of taxanes and preparations, which is applied in the direction of antineoplastic drugs and drug combinations, which can solve the problems of difficult injection preparations and slow dissolution speed, and achieve the effects of accelerating the dissolution speed, increasing the concentration, and improving the therapeutic effect
Inactive Publication Date: 2006-02-15
TIANJIN UNIV
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- Abstract
- Description
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- Application Information
AI Technical Summary
Problems solved by technology
Due to the large molecular weight of HA, its dissolution rate is very slow, and it takes 12 hours to dissolve, which brings great difficulties to injection preparations
Method used
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Experimental program
Comparison scheme
Effect test
Embodiment 1
[0018] Paclitaxel: 30mg
[0019] Ethanol: 3.0ml
[0020] Hyaluronic Acid: 200mg
[0021] Glucose: 1200mg
[0022] Propylene glycol 300mg
[0023] Cremophor EL: 2.65g
Embodiment 2
[0025] Paclitaxel: 60mg
[0026] Ethanol: 5.0ml
[0027] Solutol HS15: 5.3g
[0028] Hyaluronic Acid: 600mg
[0029] Propylene glycol: 600mg
[0030] Mannitol: 3.6g
Embodiment 3
[0032] Docetaxel: 60mg
[0033] Ethanol: 6.0ml
[0034] Hyaluronic Acid: 660mg
[0035] Glucose: 3.96g
[0036] Internal glycol: 660mg
[0037] Twain-80: 1.56g
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Abstract
The present invention discloses one kind of taxane injection. The medicine preparation consists of mainly taxol or polyenic taxol, carrier hyaluronic acid, diluent glucose or mannitol and other components, such as propylene glycol, ethanol and non-ionic features. The present invention is superior in that the target action makes the medicine accumulate around the cancer cell, with medicine concentration in pathologic tissue, high treating effect and less systemic toxic side effect.
Description
technical field [0001] The invention relates to a targeted injectable pharmaceutical preparation composed of anticancer agent paclitaxel, docetaxel and their derivatives and hyaluronic acid. Background technique [0002] Paclitaxel and docetaxel are currently the most effective taxane anticancer agents in clinical use. They are natural or semi-synthetic products isolated in the seventies from the bark or needles of yew or its species. It was subsequently found that this is a class of antitumor agents with a special mechanism of action. [0003] The main mechanism of action of taxane drugs such as paclitaxel and docetaxel is to promote microtubule polymerization, slow down the depolymerization speed of microtubules, and achieve the effect of preventing cell division. Microtubules are polymerized by tubulin. Tubulin is a protein with a molecular weight of 100,000 kDa composed of two polypeptide subunits, α and β. A dynamic equilibrium exists ...
Claims
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IPC IPC(8): A61K31/337A61P35/00
Inventor 元英进殷殿书苏伟超高世英
Owner TIANJIN UNIV