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Medicinal composition and its preparation and use

A technology of composition and medicine, which is applied in the field of pharmaceutical composition and its preparation and use, can solve the problems of low bioavailability, and achieve the effects of improving bioavailability, strengthening liver protection, and improving solubility

Inactive Publication Date: 2006-08-02
HUAZHONG UNIV OF SCI & TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The methods involved in the above documents and patents have improved the solubility of oleanolic acid to a certain extent, but there is still the problem of low bioavailability

Method used

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  • Medicinal composition and its preparation and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Weigh 6 g of oleanolic acid crude drug, 20 g of Tween-80, and 10 g of lecithin for injection and put them in 500 ml of water, and stir with a high-shear mixing emulsifier at a speed of 6000 r / min for 2 hours. Then place it in a high-pressure milk homogenizer, control the pressure to 900 bar, and the number of cycles is 10 times to obtain the oleanolic acid pharmaceutical composition. Detected with a laser particle size analyzer, the average particle diameter is 135.7nm, and the polydispersity coefficient value is 0.214.

Embodiment 2

[0042]Weigh 20 g of oleanolic acid crude drug, 10 g of Span-60, and 50 g of soybean lecithin, put them in 200 ml of water, and stir with a high-shear mixing emulsifier at a speed of 3000 r / min for 50 minutes. Then place it in a high-pressure milk homogenizer, control the pressure to 600 bar, and the number of cycles to 8 times to obtain the oleanolic acid pharmaceutical composition. Detected with a laser particle size analyzer, the average particle diameter is 312.5nm, and the polydispersity coefficient value is 0.275.

Embodiment 3

[0044] Weigh 10 g of oleanolic acid crude drug and 15 g of poloxamer F-68, put them in 200 ml of water, and stir with a powerful electromagnetic stirrer at a speed of 500 r / min for 2 hours. Then place it in a high-pressure milk homogenizer, control the pressure to 1200 bar, and the number of cycles is 6 times, and prepare the obtained oleanolic acid pharmaceutical composition. Detected with a laser particle size analyzer, the average particle diameter is 200.2nm, and the polydispersity coefficient value is 0.147.

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Abstract

A composite medicine in the form of tablet, capsule, suspension, or injection for protecting liver is prepared from oleanolic acid, surfactant and water. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to a pharmaceutical composition and its preparation method and application. Background technique [0002] Oleanolic acid is a pentacyclic triterpenoid compound, which is widely distributed in the plant kingdom in the form of free or combined glycosides, such as in plants such as gallbladder, Ligustrum lucidum, and cypress. Since it was used in the treatment of hepatitis in the last century, new pharmacological effects such as liver-protecting and enzyme-lowering effects, blood sugar-lowering effects, anti-platelet aggregation effects, anti-tumor effects, anti-viral effects, effects on the immune system and allergies, and effects on chromosomes The protective effect of damage has been discovered and gradually deepened. Oleanolic acid is clinically used to treat jaundice hepatitis, chronic persistent hepatitis and chronic active hepatitis. At present, there are oleanolic acid tablets, Zangyinchen capsules, oleanolic acid capsules a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/704A61K36/14A61K36/638A61K9/20A61K9/48A61K9/10A61P1/16A61P31/12A61P3/10A61P7/02A61P35/00A61P37/00
Inventor 杨祥良徐辉碧刘卫陈亚军易涛阮健
Owner HUAZHONG UNIV OF SCI & TECH
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