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Medicine composition for killing schistosome, and its prepn. method

A composition and technology for schistosomiasis, applied in the directions of botanical equipment and methods, animal repellents, plant growth regulators, etc., can solve the problems of the influence of the molluscicide effect, the low solubility, the decline of the molluscicide effect, etc. Practical application value, reducing environmental pollution, and improving solubility

Active Publication Date: 2005-11-09
HUAZHONG UNIV OF SCI & TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because of the use of organic solvents in the processing of emulsifiable concentrate, it is easy to cause environmental pollution, and it is strongly irritating to the eyes, which affects the practicability
In addition, it was found in the field application that the wettable powder of niclosamide ethanolamine salt is not ideal in wettability and suspension, and small lumps of sediment are easy to block the spraying equipment, resulting in difficulty in use and uneven concentration of the liquid solution, leading to molluscicide Decreased effect
Moreover, the toxicity of 70% ethanolamine salt wettable powder is larger than that of 50% ethanolamine salt, and it is easy to cause environmental pollution, and its practicability is not as good as that of 50% ethanolamine salt wettable powder
The wettable powder of 50% ethanolamine salt obtained the invention patent "A Wettable Powder of Niclosamide Salt" (Patent No. 94112267.0), but later found that its solubility is not high, the drug effect is not ideal, and the amount of use is large, making it Molluscicide effect is affected to some extent, field application is limited
However, the average particle diameter of the particles in the above-mentioned invention is relatively large, all at 3-10 μm, and the selected wetting agent and suspending agent can not fully play the role of wetting and suspending, and the poor wettability, The problem of low suspension rate and poor suspension stability

Method used

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  • Medicine composition for killing schistosome, and its prepn. method
  • Medicine composition for killing schistosome, and its prepn. method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Weigh 0.5g of niclosamide, 0.10g of sodium lauryl polyoxyethylene ether-23 sulfate, 0.30g of sodium methylnaphthalenesulfonate formaldehyde condensate, and 0.40g of diatomaceous earth, which have been pulverized by airflow, and mix them uniformly to prepare 8g / L of the suspension is sent into a high-pressure homogenizer, and the pressure is controlled at (300 ± 50) bar, and circulated 10 times to obtain a pharmaceutical composition. The average particle size is 975.6nm and the polydispersity coefficient is 0.516 after detection by laser particle size analyzer.

Embodiment 2

[0018] Weigh 1.0 g of niclosamide, 0.20 g of nonylphenol polyoxyethylene ether, 0.60 g of sodium naphthalenesulfonate formaldehyde condensate, and 0.80 g of bentonite that have been crushed by airflow, and mix them uniformly to prepare a 10 g / L suspension. Send it into a high-pressure homogenizer, control the pressure at (600±50) bar, and circulate 8 times to obtain the pharmaceutical composition. Detected by a laser particle size analyzer, the average particle diameter is 534.2nm, and the polydispersity coefficient is 0.261.

Embodiment 3

[0020] Weigh 2.0g of niclosamide, 0.38g of sodium dodecylsulfonate, 1.22g of ethylene oxide propylene oxide copolymer L621.22g, and 1.60g of white carbon black that have been pulverized by airflow, mix well, and prepare 9g / L The suspension is sent into a high-pressure homogenizer, the pressure is controlled at (900±50) bar, and the circulation is 6 times to obtain a pharmaceutical composition. Detected by a laser particle size analyzer, the average particle diameter is 325.4nm, and the polydispersity coefficient is 0.542.

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Abstract

A composite chemical for killing oncomlania and schistosome is prepared from teniarene, wetting agent, suspending aid, carrier and water through proportional mixing and high-pressure homogenizing.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical compositions, in particular to a pharmaceutical composition for eliminating schistosomiasis and a preparation method thereof. Background technique [0002] Schistosomiasis is a disease that seriously endangers people's health. In recent years, schistosomiasis has rebounded significantly in my country, especially in lake areas, the area of ​​oncomelania has continued to expand, acute infection and late-stage patients have increased year by year, and the epidemic situation has rebounded significantly. Using molluscicides to kill molluscs is a fast and effective way to reduce the spread of schistosomiasis. Drug treatment combined with molluscicides is still the main means of schistosomiasis prevention. In recent decades, a lot of research has been done to eliminate harmful snails at home and abroad, and tens of thousands of compounds have been screened, which cost a lot of money, manpower and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N37/48
Inventor 杨祥良陈宏杰周小顺阮健
Owner HUAZHONG UNIV OF SCI & TECH
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