Processes for making pharmaceutical oral ECB formulations and compositions
A technology for pharmaceutical preparations and compounds, which can be used in antifungal agents, resistance to vector-borne diseases, cyclic peptide components, etc., and can solve problems such as difficult preparations, short shelf life, and unstable echinocandin compounds.
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[0113] Example 1 illustrates the in situ formation of echinocandin / saccharide complexes using a fluidized bed spray method.
[0114] Solution A was prepared by adding 523.70 g of fructose to 760.0 ml of warm purified water while stirring. The solution was then cooled to room temperature.
[0115] Solution B was prepared by adding 2,850.0 ml of acetone to 950.0 ml of purified water cooled to 20-25°C while stirring. 523.70 g of compound 1(a) was slowly added to the acetone / water solution with stirring.
[0116] Slowly add solution A to solution B while stirring. This clear solution was then sprayed into granulated Mannitol 2080 (available from SPI Polyols Co. , New Castle, DE) fluidized bed. The initial inlet temperature of the apparatus was set at 30°C and then increased to 45°C after spraying was complete to remove excess solvent. Once dry, shake the bag and transfer the contents to a plastic-lined container.
[0117] This procedure yielded 3,332.7 g (90.9% yield) of fin...
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